GINS4 and PBX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GINS4	PBX4
Description		GINS complex subunit 4	PBX homeobox 4
Image			No pdb structure
GO Annotations	Cellular Component	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex	Chromatin XY Body Nucleus
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Animal Organ Morphogenesis Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Neuron Development
Pathways		Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder symptom score ( 27663945) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565) Cirrhosis (alcohol related) ( 32853455) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) LDL cholesterol ( 18193044 19060906 20686565) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived unattractiveness to mosquitoes ( 28199695) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 23974872 29483656) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Total cholesterol levels ( 30275531) Triglyceride levels (parental genotype effect) ( 30255771) Triglyceride levels in response to fenofibrate treatment (parental genotype effect) ( 30255771) Triglycerides ( 20686565 19060906 18193044)
Interacting Genes		12 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B	63 interacting genes: AIRIM ARHGEF3 BCL6 BFSP2 C14orf119 CCM2L CDKN2C CFTR CHCHD2 CLCNKA CPNE7 EIF1AD EIF3B EIF3F EXOC8 GADD45GIP1 GEM GINS4 GPANK1 HOXB2 HOXB5 HOXC5 HOXC8 HOXD4 HSBP1L1 IFT20 IPO13 KDM1A KLHL38 LMO2 MAGOHB MAPK9 MBD3 MIPOL1 NCK2 NEK6 NUTF2 OSTF1 PACSIN2 PICK1 PIH1D2 PIK3R3 PPL RANBP3 RBX1 RIPPLY1 RIPPLY2 SCNM1 SERTAD1 SMARCD1 SPANXN2 SPANXN3 SPG21 TFIP11 TRIM41 TSEN15 TSSK3 TXNDC9 UBTFL1 USHBP1 USP20 WWOX ZNF330
Entrez ID		84296	80714
HPRD ID		11583	16287
Ensembl ID		ENSG00000147536	ENSG00000105717
Uniprot IDs		Q9BRT9	Q9BYU1
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II	Protein Binding Nucleus Anterior/posterior Pattern Specification Skeletal System Morphogenesis
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