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GINS4 and POLD1
Number of citations of the paper that reports this interaction (PubMedID
21705323
)
58
Data Source:
BioGRID
(pull down)
GINS4
POLD1
Description
GINS complex subunit 4
DNA polymerase delta 1, catalytic subunit
Image
GO Annotations
Cellular Component
GINS Complex
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
CMG Complex
Nucleotide-excision Repair Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Cytosol
Membrane
Aggresome
Delta DNA Polymerase Complex
Molecular Function
Protein Binding
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
Nuclease Activity
Exonuclease Activity
Protein Binding
Zinc Ion Binding
3'-5'-DNA Exonuclease Activity
3'-5' Exonuclease Activity
Transferase Activity
Nucleotidyltransferase Activity
Hydrolase Activity
Enzyme Binding
DNA Polymerase Activity
Metal Ion Binding
Iron-sulfur Cluster Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Double-strand Break Repair Via Break-induced Replication
Inner Cell Mass Cell Proliferation
DNA Replication
DNA-templated DNA Replication
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-templated DNA Replication
DNA Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
DNA Damage Response
Response To UV
Cellular Response To UV
DNA Replication Proofreading
Fatty Acid Homeostasis
Error-free Translesion Synthesis
DNA Biosynthetic Process
Pathways
Unwinding of DNA
Unwinding of DNA
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Cytosolic iron-sulfur cluster assembly
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Drugs
Diseases
GWAS
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Obesity-related traits (
23251661
)
Interacting Genes
12 interacting genes:
-
BIN3
CTNNBIP1
DMAP1
GINS2
KIF16B
LHX8
PBX4
POLA1
POLD1
POLE
PPP1R13B
21 interacting genes:
ADAMTSL4
ATR
CCND3
CCNE1
CDK2
CDK4
CEP126
CHGB
GINS4
LASP1
MCPH1
PCNA
POLD2
POLD3
POLD4
SUMO2
TREX2
TRIM55
WRNIP1
XRCC5
YPEL3
Entrez ID
84296
5424
HPRD ID
11583
08882
Ensembl ID
ENSG00000147536
ENSG00000062822
Uniprot IDs
Q9BRT9
A0A087WYJ2
M0R2B7
P28340
Q308M6
Q59FA0
PDB IDs
2E9X
2EHO
2Q9Q
6XTX
6XTY
7PFO
7PLO
8B9D
8OK2
6S1M
6S1N
6S1O
6TNY
6TNZ
9EKB
Enriched GO Terms of Interacting Partners
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DNA Polymerase Activity
DNA-directed DNA Polymerase Activity
DNA Replication Proofreading
DNA Synthesis Involved In DNA Repair
Leading Strand Elongation
DNA Replication
DNA-templated DNA Replication
Nucleotide-excision Repair, DNA Gap Filling
DNA Repair
DNA Strand Elongation Involved In DNA Replication
Nucleotidyltransferase Activity
DNA Biosynthetic Process
Base-excision Repair, Gap-filling
DNA Strand Elongation
DNA Metabolic Process
DNA Damage Response
4 Iron, 4 Sulfur Cluster Binding
Actin Cortical Patch Localization
Regulation Of Vascular Permeability Involved In Acute Inflammatory Response
Iron-sulfur Cluster Binding
Beta-catenin-ICAT Complex
Indoleamine 2,3-dioxygenase Activity
Lagging Strand Elongation
DNA Synthesis Involved In UV-damage Excision Repair
Unidimensional Cell Growth
Tryptophan 2,3-dioxygenase Activity
Mitotic DNA Replication Initiation
Nucleobase-containing Compound Biosynthetic Process
Alpha DNA Polymerase:primase Complex
Error-free Translesion Synthesis
Delta DNA Polymerase Complex
Epsilon DNA Polymerase Complex
Single-stranded DNA 3'-5' DNA Exonuclease Activity
GINS Complex
Myoblast Migration Involved In Skeletal Muscle Regeneration
Response To Ethanol
L-tryptophan Catabolic Process To Kynurenine
Cellular Response To Stress
DNA Replication, Synthesis Of Primer
Nucleotide-excision Repair Complex
Negative Regulation Of DNA-templated Transcription Initiation
Negative Regulation Of Transcription Initiation By RNA Polymerase II
DNA Replication
DNA Repair
DNA Biosynthetic Process
DNA Synthesis Involved In DNA Repair
DNA Metabolic Process
DNA-templated DNA Replication
DNA Damage Response
DNA Strand Elongation Involved In DNA Replication
Cyclin-dependent Protein Kinase Holoenzyme Complex
Delta DNA Polymerase Complex
DNA Strand Elongation
Telomere Maintenance
Telomere Organization
Mitotic Cell Cycle Phase Transition
Cyclin D3-CDK4 Complex
Cellular Response To Stress
Cell Cycle Phase Transition
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
DNA-directed DNA Polymerase Activity
G1/S Transition Of Mitotic Cell Cycle
Translesion Synthesis
Cell Cycle G1/S Phase Transition
Cyclin E1-CDK2 Complex
DNA Synthesis Involved In UV-damage Excision Repair
Cyclin-dependent Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Leading Strand Elongation
Zeta DNA Polymerase Complex
Nucleobase-containing Compound Biosynthetic Process
Postreplication Repair
Regulation Of DNA Replication
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
MutLalpha Complex Binding
Nucleus
Regulation Of Mitotic Cell Cycle Phase Transition
Error-prone Translesion Synthesis
Chromosome Organization
Protein Localization To Chromosome, Telomeric Region
Regulation Of DNA-templated DNA Replication Initiation
Double-strand Break Repair
Response To Stress
Regulation Of Cell Cycle Phase Transition
Regulation Of Chromosome Organization
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Macromolecule Biosynthetic Process
Regulation Of DNA Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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