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GINS4 and POLA1
Number of citations of the paper that reports this interaction (PMID
21705323
)
14
Data Source:
BioGRID
(pull down)
GINS4
POLA1
Gene Name
GINS complex subunit 4 (Sld5 homolog)
polymerase (DNA directed), alpha 1, catalytic subunit
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytoplasm
Nuclear Matrix
Molecular Function
Protein Binding
Nucleotide Binding
Nucleoside Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
DNA Primase Activity
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Protein Heterodimerization Activity
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Mitotic Cell Cycle
Inner Cell Mass Cell Proliferation
DNA Strand Elongation Involved In DNA Replication
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Proliferation
Viral Process
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Synthesis of DNA
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Unwinding of DNA
Activation of the pre-replicative complex
Extension of Telomeres
Activation of the pre-replicative complex
Leading Strand Synthesis
DNA strand elongation
Polymerase switching
DNA replication initiation
Telomere Maintenance
G1/S Transition
G1/S-Specific Transcription
Mitotic G1-G1/S phases
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Chromosome Maintenance
Telomere C-strand synthesis initiation
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the lagging strand
DNA Replication Pre-Initiation
M/G1 Transition
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Cell Cycle, Mitotic
Removal of the Flap Intermediate
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
GINS1
GINS2
GINS3
POLA1
POLD1
POLE
17 interactors:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
RB1
RBMS1
SERPINA3
SMC1A
TP53
XRCC5
Entrez ID
84296
5422
HPRD ID
11583
02416
Ensembl ID
ENSG00000147536
ENSG00000101868
Uniprot IDs
Q9BRT9
A6NMQ1
P09884
PDB IDs
2E9X
2EHO
2Q9Q
1K0P
1K18
1N5G
Enriched GO Terms of Interacting Partners
?
DNA Replication
DNA-dependent DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
DNA Metabolic Process
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
Telomere Maintenance Via Telomere Lengthening
Mitotic Cell Cycle
Base-excision Repair, Gap-filling
Telomere Maintenance
DNA Biosynthetic Process
Cell Cycle
DNA Synthesis Involved In DNA Repair
Nucleotide-excision Repair, DNA Gap Filling
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
DNA Recombination
DNA Replication Initiation
Transcription-coupled Nucleotide-excision Repair
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Base-excision Repair
Nitrogen Compound Metabolic Process
Nucleotide-excision Repair
DNA Replication Proofreading
DNA Repair
Cellular Homeostasis
Leading Strand Elongation
G1/S Transition Of Mitotic Cell Cycle
Cellular Response To DNA Damage Stimulus
Lagging Strand Elongation
Chromosome Organization
Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Replication, Synthesis Of RNA Primer
Homeostatic Process
Fatty Acid Homeostasis
Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Inner Cell Mass Cell Proliferation
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Metabolic Process
In Utero Embryonic Development
DNA Metabolic Process
DNA Replication
Chromosome Organization
Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
DNA-dependent DNA Replication
Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Checkpoint
Cellular Response To DNA Damage Stimulus
Nucleobase-containing Compound Metabolic Process
DNA Repair
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Negative Regulation Of Mitotic Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Regulation Of Cell Cycle Process
Nitrogen Compound Metabolic Process
DNA Conformation Change
Positive Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Nuclear Division
Regulation Of Cell Cycle
Telomere Maintenance
Cell Division
Regulation Of Mitotic Cell Cycle Phase Transition
Ras Protein Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Damage Checkpoint
Nuclear DNA Replication
Mitotic DNA Integrity Checkpoint
Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
Positive Regulation Of Mitotic Cell Cycle
DNA Strand Elongation
G2/M Transition Of Mitotic Cell Cycle
DNA Replication Initiation
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud
?
annotations
birc5
cdca2
cdh3
cited1
dhfr
esco2
gins1
hells
mc1r
melana
melanocyte
melanocytes
melk
msg
ncapg
ncapg2
ncaph
nusap1
oca2
pax3
pbk
rad54l
recapitulate
revolutionized
segregating
subclasses
tyms
unsupervised
Tagcloud (Difference)
?
annotations
birc5
cdca2
cdh3
cited1
dhfr
esco2
gins1
hells
mc1r
melana
melanocyte
melanocytes
melk
msg
ncapg
ncapg2
ncaph
nusap1
oca2
pax3
pbk
rad54l
recapitulate
revolutionized
segregating
subclasses
tyms
unsupervised
Tagcloud (Intersection)
?