POLE and RAD17

Number of citations of the paper that reports this interaction (PMID 14500819)
8

Data Source:
HPRD (in vitro, in vivo)

		POLE	RAD17
Gene Name		polymerase (DNA directed), epsilon, catalytic subunit	RAD17 homolog (S. pombe)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair In Utero Embryonic Development DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Regulation Of Phosphorylation
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases	G2/M Checkpoints Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE3 POLE4 RAD17 STK19 TOPBP1 XRCC5	16 interactors: ATM ATR HUS1 MCM7 NHP2L1 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 RFC5 USP20
Entrez ID		5426	5884
HPRD ID		07177	09124
Ensembl ID		ENSG00000177084	ENSG00000152942
Uniprot IDs		F5H1D6 Q07864	O75943
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Biosynthetic Process DNA Replication Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication DNA Repair Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling DNA Recombination Cellular Response To Stress Chromosome Organization Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Translesion Synthesis Mitotic Cell Cycle Process Nucleotide-excision Repair Nitrogen Compound Metabolic Process Cellular Metabolic Process Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process DNA Replication Initiation Histone H3 Acetylation Peptidyl-lysine Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Homeostasis Organelle Organization Cell Proliferation Homeostatic Process Mismatch Repair	Cellular Response To DNA Damage Stimulus DNA Repair DNA Replication DNA Metabolic Process Cell Cycle Process Cellular Response To Stress DNA Recombination Telomere Maintenance Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Damage Checkpoint Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Cell Cycle Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Checkpoint DNA-dependent DNA Replication Response To Stress Response To Ionizing Radiation Nucleobase-containing Compound Metabolic Process Cellular Response To Ionizing Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleotide-excision Repair Chromosome Organization Nitrogen Compound Metabolic Process Cellular Response To Radiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Biosynthetic Process Cellular Response To Stimulus Cellular Metabolic Process Double-strand Break Repair Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Response To Gamma Radiation Organelle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Mitotic Cell Cycle Homeostatic Process
Tagcloud ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Difference) ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acetylcysteine antioxidant chk1 converted depleted driving experiencing gamma h2ax h2o2 illustrate instability intertwined micronuclei mildly mimics mn nac p400 pan peroxide promoting redox reinforce rnai ros sesn1 stressed subclass
Tagcloud (Intersection) ?