POLE and STK19

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		POLE	STK19
Gene Name		polymerase (DNA directed), epsilon, catalytic subunit	serine/threonine kinase 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Nucleus
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair In Utero Embryonic Development DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Protein Phosphorylation
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23577725) Hematology traits ( 23263863) Prostate cancer ( 23535732)
Protein-Protein Interactions		12 interactors: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE3 POLE4 RAD17 STK19 TOPBP1 XRCC5	8 interactors: BHLHE40 POLE POLR2G PRAME SF3B4 SLC29A1 SP3 TRIM23
Entrez ID		5426	8859
HPRD ID		07177	07281
Ensembl ID		ENSG00000177084	ENSG00000204344
Uniprot IDs		F5H1D6 Q07864	P49842
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Biosynthetic Process DNA Replication Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication DNA Repair Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling DNA Recombination Cellular Response To Stress Chromosome Organization Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Translesion Synthesis Mitotic Cell Cycle Process Nucleotide-excision Repair Nitrogen Compound Metabolic Process Cellular Metabolic Process Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process DNA Replication Initiation Histone H3 Acetylation Peptidyl-lysine Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Homeostasis Organelle Organization Cell Proliferation Homeostatic Process Mismatch Repair	Nucleobase-containing Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Uridine Transport Regulation Of MRNA Processing Nucleotide-excision Repair Pyrimidine Nucleoside Transport Cellular Metabolic Process RNA Metabolic Process Base-excision Repair, Gap-filling Transcription From RNA Polymerase II Promoter Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Embryonic Process Involved In Female Pregnancy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Enucleate Erythrocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Granulocyte Differentiation Sleep DNA Synthesis Involved In DNA Repair RNA Splicing Nucleotide-excision Repair, DNA Gap Filling Regulation Of MRNA 3'-end Processing Nucleoside Transmembrane Transport Monocyte Differentiation Nucleoside Transport Natural Killer Cell Differentiation Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of MRNA Catabolic Process Regulation Of RNA Metabolic Process Megakaryocyte Differentiation Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gene Expression Definitive Hemopoiesis Nuclear DNA Replication Telomere Maintenance Via Recombination Negative Regulation Of Biosynthetic Process
Tagcloud ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma melanomas nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib
Tagcloud (Difference) ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acral amine awareness braf causative ctla4 dabrafenib etc exceptionally grin2a holds imatinib immunosuppressive instances mandatory mek melanoma melanomas nevertheless nras ppp6c prex2 rac1 revolution substitutions threonine trrap ultraviolet vemurafenib
Tagcloud (Intersection) ?