POLE and ABHD16A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLE	ABHD16A
Description		DNA polymerase epsilon, catalytic subunit	abhydrolase domain containing 16A, phospholipase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' DNA Exonuclease Activity Transferase Activity Nucleotidyltransferase Activity Hydrolase Activity DNA Polymerase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Monoacylglycerol Lipase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication Leading Strand Elongation DNA Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling DNA Damage Response DNA Replication Proofreading Embryonic Organ Development DNA Biosynthetic Process	Lipid Metabolic Process Phosphatidylserine Catabolic Process Monoacylglycerol Catabolic Process Prostaglandin Catabolic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: ABHD16A CFTR CLSPN GINS4 MDM2 PCNA POLA1 POLD4 POLE4 RAD17 TOPBP1 WHR1 XRCC5	69 interacting genes: AGPAT3 AQP6 AQP7 ATP5MC3 ATP5PF BRI3 CBARP CIDEB CREB3 CYP1A2 DNAJC1 DTX2 EBP ERGIC3 FDPS FKBP7 GDAP1 GJA5 GOLT1A GORAB GPR152 GPRC5C GYPC HM13 HNRNPA1 HSD17B13 IFITM1 IFITM3 ITGAM LTA MLH1 MT-ND3 MT-ND4 PERP PILRB PKMYT1 POLE PRAF2 PTGS2 RETREG3 RHBDD2 RHBDL1 RNF5 SAFB SEC22B SERF1A SERF1B SLC10A1 SLC30A2 SLC7A8 SPAG4 SPAG7 STMN4 STX1B TM4SF19 TMEM139 TMEM143 TMEM147 TMEM14B TMEM222 TMEM237 TMEM31 TMEM65 TSPAN2 UNC93A UPF1 VAMP5 VMA21 WBP1L
Entrez ID		5426	7920
HPRD ID		07177	15929
Ensembl ID		ENSG00000177084	ENSG00000204427
Uniprot IDs		Q07864	A0A1U9X777 B3KNX9 O95870
PDB IDs		5VBN 7PFO 7PLO 9B8S 9B8T 9F6D 9F6E 9F6F 9F6I 9F6J 9F6K 9F6L
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Response To Stress DNA Damage Response Cellular Response To Stress DNA Biosynthetic Process Mitotic DNA Replication Checkpoint Signaling DNA-templated DNA Replication DNA Replication DNA Replication Checkpoint Signaling DNA-directed DNA Polymerase Activity Nucleic Acid Metabolic Process Leading Strand Elongation DNA Synthesis Involved In DNA Repair Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Male Germ Cell Nucleus Mitotic G2/M Transition Checkpoint Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Strand Elongation Involved In DNA Replication Double-strand Break Repair Protein-containing Complex Chromatin-protein Adaptor Activity DNA Damage Checkpoint Signaling Response To Lipid DNA Strand Elongation Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Cell Cycle G2/M Phase Transition Nucleoplasm Protein Localization To Site Of Double-strand Break DNA Replication Initiation Cellular Response To Gamma Radiation Recycling Endosome Regulation Of Mitotic Cell Cycle Phase Transition Recombinational Repair Response To Hormone Response To Ionizing Radiation Chromosome Organization Protein-containing Complex Binding Protein Localization To Organelle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Sphingolipid Mediated Signaling Pathway High-density Lipoprotein Particle Receptor Activity	Membrane Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum
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