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POLE and POLA1
Number of citations of the paper that reports this interaction (PMID
9563011
)
6
Data Source:
HPRD
(in vivo, in vitro)
POLE
POLA1
Gene Name
polymerase (DNA directed), epsilon, catalytic subunit
polymerase (DNA directed), alpha 1, catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Alpha DNA Polymerase:primase Complex
Nucleolus
Cytoplasm
Nuclear Matrix
Molecular Function
Nucleotide Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Zinc Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Nucleotide Binding
Nucleoside Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
DNA Primase Activity
Protein Binding
Protein Kinase Binding
Metal Ion Binding
Protein Heterodimerization Activity
4 Iron, 4 Sulfur Cluster Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
In Utero Embryonic Development
DNA Replication
DNA Replication Initiation
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Semi-conservative Replication
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA Replication, Synthesis Of RNA Primer
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Leading Strand Elongation
Lagging Strand Elongation
DNA Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Proliferation
Viral Process
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
Nucleotide Excision Repair
Synthesis of DNA
Chromosome Maintenance
Telomere C-strand synthesis initiation
Gap-filling DNA repair synthesis and ligation in TC-NER
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Extension of Telomeres
M/G1 Transition
Activation of the pre-replicative complex
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
DNA replication initiation
Global Genomic NER (GG-NER)
Telomere Maintenance
G1/S Transition
Transcription-coupled NER (TC-NER)
Mitotic G1-G1/S phases
Activation of the pre-replicative complex
Extension of Telomeres
Activation of the pre-replicative complex
Leading Strand Synthesis
DNA strand elongation
Polymerase switching
DNA replication initiation
Telomere Maintenance
G1/S Transition
G1/S-Specific Transcription
Mitotic G1-G1/S phases
E2F mediated regulation of DNA replication
Polymerase switching on the C-strand of the telomere
Chromosome Maintenance
Telomere C-strand synthesis initiation
Synthesis of DNA
Lagging Strand Synthesis
Processive synthesis on the lagging strand
DNA Replication Pre-Initiation
M/G1 Transition
Telomere C-strand (Lagging Strand) Synthesis
S Phase
Cell Cycle, Mitotic
Removal of the Flap Intermediate
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Cladribine
Clofarabine
Fludarabine
Nelarabine
Diseases
GWAS
Protein-Protein Interactions
12 interactors:
GINS4
MDM2
PCNA
POLA1
POLD4
POLE2
POLE3
POLE4
RAD17
STK19
TOPBP1
XRCC5
17 interactors:
CCNA2
CCNB1
CDC45
CDK1
CDK2
CDK2AP1
GINS4
HELB
PARP1
POLA2
POLE
RB1
RBMS1
SERPINA3
SMC1A
TP53
XRCC5
Entrez ID
5426
5422
HPRD ID
07177
02416
Ensembl ID
ENSG00000177084
ENSG00000101868
Uniprot IDs
F5H1D6
Q07864
A6NMQ1
P09884
PDB IDs
1K0P
1K18
1N5G
Enriched GO Terms of Interacting Partners
?
DNA Metabolic Process
DNA Biosynthetic Process
DNA Replication
Telomere Maintenance Via Semi-conservative Replication
Telomere Maintenance
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA-dependent DNA Replication
DNA Repair
Mitotic Cell Cycle
Nucleotide-excision Repair, DNA Gap Filling
DNA Recombination
Cellular Response To Stress
Chromosome Organization
Leading Strand Elongation
Transcription-coupled Nucleotide-excision Repair
Cell Cycle
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cell Cycle Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Translesion Synthesis
Mitotic Cell Cycle Process
Nucleotide-excision Repair
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Postreplication Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Stress
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Biosynthetic Process
DNA Replication Initiation
Histone H3 Acetylation
Peptidyl-lysine Modification
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cellular Homeostasis
Organelle Organization
Cell Proliferation
Homeostatic Process
Mismatch Repair
DNA Metabolic Process
DNA Replication
Chromosome Organization
Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
DNA-dependent DNA Replication
Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Checkpoint
Cellular Response To DNA Damage Stimulus
Nucleobase-containing Compound Metabolic Process
DNA Repair
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Organelle Organization
Negative Regulation Of Mitotic Cell Cycle
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Regulation Of Cell Cycle Process
Nitrogen Compound Metabolic Process
DNA Conformation Change
Positive Regulation Of Cell Cycle
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Mitotic Nuclear Division
Regulation Of Cell Cycle
Telomere Maintenance
Cell Division
Regulation Of Mitotic Cell Cycle Phase Transition
Ras Protein Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Damage Checkpoint
Nuclear DNA Replication
Mitotic DNA Integrity Checkpoint
Biosynthetic Process
DNA Strand Elongation Involved In DNA Replication
Positive Regulation Of Mitotic Cell Cycle
DNA Strand Elongation
G2/M Transition Of Mitotic Cell Cycle
DNA Replication Initiation
Regulation Of DNA Replication
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Tagcloud
?
absolute
bfgf
bmp
cdnas
disruption
dorsal
embryo
embryogenesis
explants
fate
globin
helix
hematopoietic
inductive
lineages
marginal
mesoderm
myod
organogenesis
participates
patterning
progenitors
requirement
scl
specify
specifying
ventral
xenopus
zone
Tagcloud (Difference)
?
absolute
bfgf
bmp
cdnas
disruption
dorsal
embryo
embryogenesis
explants
fate
globin
helix
hematopoietic
inductive
lineages
marginal
mesoderm
myod
organogenesis
participates
patterning
progenitors
requirement
scl
specify
specifying
ventral
xenopus
zone
Tagcloud (Intersection)
?