POLE and POLE4

Number of citations of the paper that reports this interaction (PMID 10801849)
20

Data Source:
HPRD (in vitro)

		POLE	POLE4
Gene Name		polymerase (DNA directed), epsilon, catalytic subunit	polymerase (DNA-directed), epsilon 4, accessory subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Epsilon DNA Polymerase Complex	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Zinc Ion Binding 4 Iron, 4 Sulfur Cluster Binding	DNA-directed DNA Polymerase Activity Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair In Utero Embryonic Development DNA Replication DNA Replication Initiation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication	Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Nucleotide Excision Repair Synthesis of DNA Chromosome Maintenance Telomere C-strand synthesis initiation Gap-filling DNA repair synthesis and ligation in TC-NER Activation of the pre-replicative complex DNA Replication Pre-Initiation Repair synthesis for gap-filling by DNA polymerase in TC-NER Extension of Telomeres M/G1 Transition Activation of the pre-replicative complex S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER DNA replication initiation Global Genomic NER (GG-NER) Telomere Maintenance G1/S Transition Transcription-coupled NER (TC-NER) Mitotic G1-G1/S phases
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE3 POLE4 RAD17 STK19 TOPBP1 XRCC5	6 interactors: HSPA13 NFYB POLE POLE2 POLE3 UBE3A
Entrez ID		5426	56655
HPRD ID		07177	16238
Ensembl ID		ENSG00000177084
Uniprot IDs		F5H1D6 Q07864	Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Biosynthetic Process DNA Replication Telomere Maintenance Via Semi-conservative Replication Telomere Maintenance Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication DNA Repair Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling DNA Recombination Cellular Response To Stress Chromosome Organization Leading Strand Elongation Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Translesion Synthesis Mitotic Cell Cycle Process Nucleotide-excision Repair Nitrogen Compound Metabolic Process Cellular Metabolic Process Postreplication Repair Double-strand Break Repair Via Nonhomologous End Joining Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle Biosynthetic Process DNA Replication Initiation Histone H3 Acetylation Peptidyl-lysine Modification Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Homeostasis Organelle Organization Cell Proliferation Homeostatic Process Mismatch Repair	DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Replication Telomere Maintenance Via Telomere Lengthening DNA Replication Initiation Transcription-coupled Nucleotide-excision Repair Telomere Maintenance Nucleotide-excision Repair DNA-dependent DNA Replication Sperm Entry G1/S Transition Of Mitotic Cell Cycle Chromosome Organization Error-prone Translesion Synthesis DNA Metabolic Process DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Base-excision Repair, Gap-filling Translesion Synthesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Synthesis Involved In DNA Repair Prostate Gland Growth Postreplication Repair Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Mitotic Cell Cycle Process Protein K48-linked Ubiquitination Cellular Homeostasis Cellular Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Protein Autoubiquitination Mitotic Cell Cycle Histone H3 Acetylation Cellular Response To DNA Damage Stimulus Nitrogen Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Base-excision Repair Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Metabolic Process Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2
Tagcloud (Difference) ?		absolute bfgf bmp cdnas disruption dorsal embryo embryogenesis explants fate globin helix hematopoietic inductive lineages marginal mesoderm myod organogenesis participates patterning progenitors requirement scl specify specifying ventral xenopus zone	acetylase acetylating ada ada2 ada3 atac chrac17 coregulators fam48a gcn5 hereafter invertebrates machineries map3 map3k7 mbip nc2beta p38ip paralogous pole3 saga spt spt20 spt3 staf36 staga taf9 wdr5 yeats2
Tagcloud (Intersection) ?