RRN3 and POLR1A

Number of citations of the paper that reports this interaction (PMID 11250903)
52

Data Source:
HPRD (in vivo, in vitro)

		RRN3	POLR1A
Gene Name		RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	polymerase (RNA) I polypeptide A, 194kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm
	Molecular Function	RNA Polymerase Binding	RNA Polymerase I Activity DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	7 interactors: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4
Entrez ID		54700	25885
HPRD ID		12004	10161
Ensembl ID		ENSG00000085721	ENSG00000068654
Uniprot IDs		F5H148 Q9NYV6	O95602 Q9H6T2
PDB IDs
Enriched GO Terms of Interacting Partners?		Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly	Nucleolus Organization Positive Regulation Of Protein Export From Nucleus Protein-DNA Complex Assembly DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of Protein Export From Nucleus Transcription From RNA Polymerase I Promoter RNA Metabolic Process Positive Regulation Of Cytokine Production Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Nucleobase-containing Compound Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Nucleocytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Nucleus Organization Regulation Of Cell Death RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Macromolecular Complex Assembly Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Gene Expression Maintenance Of DNA Repeat Elements Innate Immune Response Cellular Macromolecule Biosynthetic Process Ribosome Biogenesis Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Positive Regulation Of Intracellular Transport Negative Regulation Of Cell Death Cytoplasm Organization Myoblast Fate Commitment Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Protein Transport Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated
Tagcloud (Difference) ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated
Tagcloud (Intersection) ?