RRN3 and TAF1C

Number of citations of the paper that reports this interaction (PubMedID 11250903)
41

Data Source:
HPRD (in vitro, in vivo)

		RRN3	TAF1C
Description		RNA polymerase I transcription factor RRN3	TATA-box binding protein associated factor, RNA polymerase I subunit C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Fibrillar Center Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Protein Binding RNA Polymerase Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Ribosome Biogenesis Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Homeostasis Of Number Of Cells Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Initiation	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fruit consumption ( 32066663) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Serum metabolite levels ( 33031748) Triglyceride levels ( 32154731)	Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	14 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1 VPS26C
Entrez ID		54700	9013
HPRD ID		12004	05364
Ensembl ID		ENSG00000085721	ENSG00000103168
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	B3KUE8 Q15572
PDB IDs		7OBA
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase I RNA Polymerase Transcription Factor SL1 Complex DNA-templated Transcription Nucleolus RRNA Transcription Nucleoplasm Cyclin E1-CDK2 Complex RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Nucleic Acid Metabolic Process RNA Metabolic Process Macromolecule Metabolic Process Fibrillar Center Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cyclin-dependent Protein Kinase Holoenzyme Complex RRNA Metabolic Process Transcription Preinitiation Complex Assembly RNA Polymerase I Core Factor Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Negative Regulation Of Protein Localization To Nucleolus Nucleologenesis Nucleotidyltransferase Activity Telomere Maintenance Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Ribonucleoside Binding X Chromosome Telomere Organization Stereocilium Membrane RNA Polymerase I General Transcription Initiation Factor Activity Viral Translational Termination-reinitiation Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity	RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Core Promoter Sequence-specific DNA Binding Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase I Transcription Preinitiation Complex Assembly Protein-DNA Complex Assembly RNA Polymerase Transcription Factor SL1 Complex Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Protein-containing Complex Assembly RNA Metabolic Process Protein-containing Complex Organization DNA-templated Transcription Initiation RRNA Transcription RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I RNA Polymerase I General Transcription Initiation Factor Activity Male Germ Cell Nucleus Macromolecule Metabolic Process Nucleoplasm Cellular Component Assembly Nucleus Regulation Of DNA-templated Transcription Initiation Nucleolus DNA Binding Core Promoter Sequence-specific DNA Binding Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Fibroblast Proliferation Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Histone H3K23ac Reader Activity RNA Polymerase I Core Factor Complex RNA Polymerase I General Transcription Initiation Factor Binding RRNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Euchromatin MRNA Transcription Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Thymidine Kinase Activity Oligodendrocyte Apoptotic Process P53 Binding Negative Regulation Of Pentose-phosphate Shunt
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