RRN3 and TAF1C

Number of citations of the paper that reports this interaction (PMID 11250903)
52

Data Source:
HPRD (in vivo, in vitro)

		RRN3	TAF1C
Gene Name		RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleoplasm
	Molecular Function	RNA Polymerase Binding	DNA Binding Protein Binding
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	Chromatin Silencing At RDNA Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression SIRT1 negatively regulates rRNA Expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS			Autism ( 22843504) Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	14 interactors: H2AFX POLR1E RRN3 SMN1 TAF1A TAF1B TAF1D TBP TK1 TP53 TRIM24 TTR UBTF UFD1L
Entrez ID		54700	9013
HPRD ID		12004	05364
Ensembl ID		ENSG00000085721	ENSG00000103168
Uniprot IDs		F5H148 Q9NYV6	B3KUE8 Q15572
PDB IDs
Enriched GO Terms of Interacting Partners?		Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly	Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Chromatin Silencing Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression RRNA Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Gene Silencing Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter RNA Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Transcription From RNA Polymerase III Promoter Cellular Macromolecular Complex Assembly Cellular Component Assembly Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Metabolic Process Fetal Process Involved In Parturition Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromitophagy Skeletal Muscle Cell Proliferation
Tagcloud ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1b tata tbp tumourigenesis ubf
Tagcloud (Difference) ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tfiib upstream validated	analysed blocking c8 coding crc frameshift gc harboured heterogeneity instability intratumoural ith microsatellite mononucleotide msi mss mutational regional ribosomal rrna somatic strand summary taf1a taf1b tumourigenesis ubf
Tagcloud (Intersection) ?		tata tbp