RRN3 and MYO1C

Number of citations: 0 (PubMedID 15558034)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vitro, in vivo)

		RRN3	MYO1C
Name		RNA polymerase I transcription factor RRN3	myosin IC
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Stress Fiber Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Filament Plasma Membrane Microvillus Brush Border Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Membrane Lateral Plasma Membrane Myosin Complex Unconventional Myosin Complex Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Filamentous Actin Stereocilium Ruffle Membrane Cell Projection Membrane Raft Phagocytic Vesicle Stereocilium Membrane Extracellular Exosome B-WICH Complex Plasma Membrane Bounded Cell Projection
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Protein Binding RNA Polymerase Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Signaling Receptor Binding Protein Binding Calmodulin Binding ATP Binding Small GTPase Binding Actin Filament Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly In Utero Embryonic Development DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Ribosome Biogenesis Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Homeostasis Of Number Of Cells Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription Initiation	Chromatin Remodeling Protein Targeting To Membrane Endocytosis Actin Filament Organization Actin Filament-based Movement Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Type II Interferon Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cellular Response To Insulin Stimulus Regulation Of Bicellular Tight Junction Assembly
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Fruit consumption ( 32066663 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) Serum metabolite levels ( 33031748 ) Triglyceride levels ( 32154731 )	Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 ) Mean platelet volume ( 32888494 ) Neutrophil count ( 32888494 ) Pulse pressure ( 30578418 ) White blood cell count ( 32888494 )
Novel Interactors		None recorded	1 novel interactors: MYH10
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	11 interacting genes: BAZ1B CBL CDC42 KHDRBS1 NEIL3 PTEN RBFOX2 RBPMS RRN3 SEPTIN9 WEE2-AS1
Entrez ID		54700	4641
HPRD ID		12004	09411
Ensembl ID		ENSG00000085721	ENSG00000197879
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	F5H6E2 O00159
PDB IDs		7OBA	4BYF
GO Terms Enriched among Interactors		Transcription By RNA Polymerase I RNA Polymerase Transcription Factor SL1 Complex DNA-templated Transcription Nucleolus RRNA Transcription Nucleoplasm Cyclin E1-CDK2 Complex RNA Polymerase I Transcription Regulator Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase I Complex Nucleic Acid Metabolic Process RNA Metabolic Process Macromolecule Metabolic Process Fibrillar Center Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cyclin-dependent Protein Kinase Holoenzyme Complex RRNA Metabolic Process Transcription Preinitiation Complex Assembly RNA Polymerase I Core Factor Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Negative Regulation Of Protein Localization To Nucleolus Nucleologenesis Nucleotidyltransferase Activity Telomere Maintenance Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Ribonucleoside Binding X Chromosome Telomere Organization Stereocilium Membrane RNA Polymerase I General Transcription Initiation Factor Activity Viral Translational Termination-reinitiation Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Histone Kinase Activity	Regulation Of Alternative MRNA Splicing, Via Spliceosome Dendritic Spine Morphogenesis Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleus Localization Dendritic Spine Organization Nuclear Migration Molecular Function Inhibitor Activity Regulation Of RNA Splicing Protein Tyrosine Kinase Binding Neuron Projection Organization Postsynapse Organization Nucleic Acid Binding Establishment Of Organelle Localization Neuron Projection Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Histone H2AXY142 Kinase Activity Grb2-Sos Complex MRNA Binding MCM Complex Binding Cell Projection Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction GBD Domain Binding Storage Vacuole Fourth Ventricle Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Regulation Of MRNA Metabolic Process Neuron Projection Stress Fiber Positive Regulation Of Transport Endothelin Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Myosin II Filament Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission RNA Polymerase I Core Binding SH3 Domain Binding Regulation Of Rap Protein Signal Transduction Actin Filament-based Process Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Chromosome Condensation