RRN3 and MYO1C

Number of citations of the paper that reports this interaction (PMID 15558034)
74

Data Source:
HPRD (in vivo, in vitro)

		RRN3	MYO1C
Gene Name		RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	myosin IC
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Stress Fiber Ruffle Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Microvillus Brush Border Basal Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Unconventional Myosin Complex Filamentous Actin Membrane Raft Myosin I Complex Stereocilium Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase Binding	Motor Activity Actin Binding Receptor Binding Protein Binding Calmodulin Binding ATP Binding Protein C-terminus Binding Ral GTPase Binding Actin-dependent ATPase Activity
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	Protein Targeting Protein Targeting To Membrane Positive Regulation Of Cell Migration Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response MRNA Transport Membrane Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Tight Junction Assembly
Pathways		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance	Translocation of GLUT4 to the plasma membrane Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	4 interactors: BAZ1B CBL KHDRBS1 RRN3
Entrez ID		54700	4641
HPRD ID		12004	09411
Ensembl ID		ENSG00000085721	ENSG00000197879
Uniprot IDs		F5H148 Q9NYV6	F5H6E2 O00159
PDB IDs
Enriched GO Terms of Interacting Partners?		Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly	Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Nucleolus Organization Cytoplasm Organization Regulation Of RNA Metabolic Process Chromatin-mediated Maintenance Of Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Export From Nucleus Positive Regulation Of Translational Initiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Gene Expression, Epigenetic Transcription, DNA-templated Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation RNA Biosynthetic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Cell Proliferation Transcription From RNA Polymerase I Promoter Positive Regulation Of Transport Positive Regulation Of Receptor-mediated Endocytosis Histone Phosphorylation Positive Regulation Of Receptor Activity Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death RNA Metabolic Process Negative Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Signal Transduction Regulation Of Translational Initiation Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of ERBB Signaling Pathway
Tagcloud ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated	actin attenuates blocked cargo cooperatively cytoskeletal deletion diminished dominant essential ikappab ikk intact interaction irs lacking modulator motor necrosis nemo network phosphorylates precise requires ruffles ser307 silencing tnf trafficking
Tagcloud (Difference) ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated	actin attenuates blocked cargo cooperatively cytoskeletal deletion diminished dominant essential ikappab ikk intact interaction irs lacking modulator motor necrosis nemo phosphorylates precise requires ruffles ser307 silencing tnf trafficking
Tagcloud (Intersection) ?		network