RRN3 and PPP2R2A

Number of citations of the paper that reports this interaction (PMID 15004009)
81

Data Source:
BioGRID (pull down)

		RRN3	PPP2R2A
Gene Name		RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	protein phosphatase 2, regulatory subunit B, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Protein Phosphatase Type 2A Complex Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	In Utero Embryonic Development Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Nucleolus Organization Cytoplasm Organization Cell Proliferation Gene Expression Ribosome Biogenesis Positive Regulation Of Transcription, DNA-templated Homeostasis Of Number Of Cells Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of DNA-templated Transcription, Initiation	G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Envelope Reassembly Signal Transduction Gene Expression Response To Morphine Regulation Of Catalytic Activity
Pathways		RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance	Nonsense-Mediated Decay (NMD) G1 Phase G2/M Transition Mitotic Anaphase Cell Cycle, Mitotic M Phase Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Cyclin D associated events in G1 Cyclin A/B1 associated events during G2/M transition Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic G2-G2/M phases Mitotic G1-G1/S phases Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Height ( 23563607)
Protein-Protein Interactions		10 interactors: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	12 interactors: ATR CHEK2 GRIN1 GRIN2D MTOR NDRG1 PPP2CA PPP2R1A PPP2R1B RRN3 STRN3 TGFBR1
Entrez ID		54700	5520
HPRD ID		12004	09223
Ensembl ID		ENSG00000085721	ENSG00000221914
Uniprot IDs		F5H148 Q9NYV6	P63151
PDB IDs			3DW8
Enriched GO Terms of Interacting Partners?		Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Chromatin Silencing At RDNA Chromatin Silencing Gene Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RRNA Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Expression Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Metabolic Process Nucleologenesis RNA Metabolic Process RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of DNA-dependent DNA Replication Initiation G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Mitotic Cell Cycle Process Post-embryonic Hemopoiesis Nucleolus Organization Cellular Metabolic Process Mitotic Cell Cycle Regulation Of DNA-dependent DNA Replication Initiation Mitotic Nuclear Envelope Reassembly Glomerular Visceral Epithelial Cell Development Regulation Of Tight Junction Assembly Metabolic Process Nuclear Envelope Reassembly	Regulation Of DNA Replication Regulation Of Signaling Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Regulation Of Signal Transduction Nuclear Envelope Reassembly Positive Regulation Of Transcription, DNA-templated Peptidyl-serine Phosphorylation Nucleus Organization Replicative Senescence Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Double-strand Break Repair Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Cellular Biosynthetic Process Apoptotic Process Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Programmed Cell Death Startle Response Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Cellular Response To Heat Death Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Fibroblast Growth Factor Negative Regulation Of Signal Transduction Inactivation Of MAPK Activity Cell Development Response To Abiotic Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Regulation Of Cellular Component Organization Negative Regulation Of Signaling Positive Regulation Of Cell Death Developmental Process Synaptic Transmission, Glutamatergic
Tagcloud ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated	22q13 alterations analyzing brca1 candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Difference) ?		architecture assemble assembles assembly binds biochemical cf comprising conserved cross extend insight interconnected linking network orthologous pol preinitiation providing rrn11 rrn6 rrn7 sl1 subunits tata tbp tfiib upstream validated	22q13 alterations analyzing brca1 candidates computational developments drive driver estimates estimating generations genomes genomic identifies instability lineage mutator mutators neutral passenger passengers prkdc somatic take technologies throughput timing tumorigenesis
Tagcloud (Intersection) ?