ANTXR1 and RBCK1

Number of citations of the paper that reports this interaction (PubMedID 34285210)
58

Data Source:
BioGRID (two hybrid)

		ANTXR1	RBCK1
Description		ANTXR cell adhesion molecule 1	RANBP2-type and C3HC4-type zinc finger containing 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Lamellipodium Membrane Filopodium Membrane Cell Projection	Cytosol LUBAC Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Metal Ion Binding Actin Filament Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Sequestering Activity Ubiquitin Ligase Activator Activity
	Biological Process	Blood Vessel Development Epidermal Growth Factor Receptor Signaling Pathway Actin Cytoskeleton Organization Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Extracellular Matrix Assembly	Protein Polyubiquitination Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Regulation Of Primary Metabolic Process Protein Linear Polyubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs		MDX-1303
Diseases
GWAS		Alzheimer's disease ( 30636644) Appendicular lean mass ( 33097823) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Height ( 21998595 31562340) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 29235454 29617998 29785010 30054594 31959993) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Periodontitis (stage III/IV grade C) ( 33745150)	Femur bone mineral density x serum urate levels interaction ( 34046847) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: ASB10 BCL2L1 BRCA1 DTX3L HDAC2 LRP6 RBCK1 RNF182 TRIM35 TRIM51	71 interacting genes: ANKRD35 ANTXR1 APP ARNT2 BACH1 CREB5 CREBBP ENKD1 GLYCTK HGS HOXA1 HOXC8 IL16 IREB2 KANK2 LNX1 MAP3K1 MAPKBP1 MKRN2 MTSS1 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMA1 PSMD4 RELA RIPPLY3 RNF181 RNF26 RNF31 SHARPIN SMURF1 SOCS6 SYCE1 TNF TNFAIP3 TP53 TRAF1 TRIM25 TRIM65 TRIML1 TSSK3 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7 ZNF414
Entrez ID		84168	10616
HPRD ID		05913	16643
Ensembl ID		ENSG00000169604	ENSG00000125826
Uniprot IDs		H0YC24 Q53FL1 Q96EC6 Q9H6X2	A0A8V8TMZ2 A6PVJ6 Q9BYM8
PDB IDs		3N2N 6ADL 6ADM 6ADR 6CX1	2CRC 2LGY 4DBG 7V8E 7YUI 7YUJ 8BVL 8EAZ 8K6Q 9EGV 9EGW
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Modification Process Response To Alcohol Ubiquitin-protein Transferase Activity Response To External Biotic Stimulus Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Cycle Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Other Organism Zinc Ion Binding Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Defense Response Response To Stress Apoptotic Process In Bone Marrow Cell Defense Response To Virus Protein Polyubiquitination Positive Regulation Of Male Mating Behavior Histone H4K91 Ubiquitin Ligase Activity Protein Autoubiquitination Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell Cycle Negative Regulation Of Apoptotic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein De-2-hydroxyisobutyrylase Activity Response To Alkaloid Response To Virus Regulation Of Apoptotic Signaling Pathway Enzyme Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Damage Checkpoint Signaling Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Transferase Activity	Post-translational Protein Modification Protein Modification Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Protein Metabolic Process Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Transferase Activity Catabolic Process Ubiquitin Protein Ligase Activity Protein K48-linked Ubiquitination Cysteine-type Peptidase Activity Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-like Protein Transferase Activity Protein K11-linked Ubiquitination Protein K63-linked Ubiquitination Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Defense Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of DNA-templated Transcription Free Ubiquitin Chain Polymerization Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process
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