ANTXR1 and LRP6

Number of citations of the paper that reports this interaction (PMID 16564009)
36

Data Source:
HPRD (in vivo, in vitro)

		ANTXR1	LRP6
Gene Name		anthrax toxin receptor 1	low density lipoprotein receptor-related protein 6
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane Lamellipodium Membrane Filopodium Membrane Extracellular Vesicular Exosome	Extracellular Region Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Neuronal Cell Body Receptor Complex Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Metal Ion Binding Actin Filament Binding	Low-density Lipoprotein Receptor Activity Receptor Binding Frizzled Binding Protein Binding Wnt-protein Binding Kinase Inhibitor Activity Toxin Transporter Activity Apolipoprotein Binding Identical Protein Binding Protein Homodimerization Activity Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway
	Biological Process	Signal Transduction Pathogenesis Reproductive Process Actin Cytoskeleton Reorganization Substrate Adhesion-dependent Cell Spreading	Gastrulation With Mouth Forming Second Neural Tube Closure Negative Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Pericardium Morphogenesis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Embryonic Pattern Specification Anterior/posterior Pattern Specification Neural Crest Formation Neural Crest Cell Differentiation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cerebellum Morphogenesis Thalamus Development Cerebral Cortex Cell Migration Forebrain Radial Glial Cell Differentiation Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Formation Of Radial Glial Scaffolds Cerebral Cortex Development Regulation Of Ossification Embryonic Limb Morphogenesis Midbrain Development Midbrain-hindbrain Boundary Development Negative Regulation Of Smooth Muscle Cell Apoptotic Process Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis External Genitalia Morphogenesis Post-anal Tail Morphogenesis Cell Migration Involved In Gastrulation Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Response To Peptide Hormone Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Neural Crest Cell Differentiation Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Regulation Of Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Ossification Positive Regulation Of Bone Resorption Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Bone Remodeling Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Folic Acid Palate Development Convergent Extension Embryonic Retina Morphogenesis In Camera-type Eye Canonical Wnt Signaling Pathway Regulation Of Cell Development Face Morphogenesis Bone Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Trachea Cartilage Morphogenesis Mammary Placode Formation Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Cellular Response To Cholesterol Dopaminergic Neuron Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity Primitive Streak Formation Negative Regulation Of Canonical Wnt Signaling Pathway Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Wnt Signaling Pathway Involved In Somitogenesis Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Toxin Transport Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways			disassembly of the destruction complex and recruitment of AXIN to the membrane misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Height ( 21998595)
Protein-Protein Interactions		4 interactors: BCL2L1 BRCA1 HDAC2 LRP6	15 interactors: ANTXR1 ANTXR2 APOB ATP13A2 AXIN1 DKK1 DKK2 FZD5 FZD8 GSK3B LRRK2 MESDC1 SERPINF1 WNT1 WNT3A
Entrez ID		84168	4040
HPRD ID		05913	04617
Ensembl ID		ENSG00000169604	ENSG00000070018
Uniprot IDs		Q53FL1 Q96EC6 Q9H6X2	F5H7J9 O75581
PDB IDs		3N2N	3S2K 3S8V 3S8Z 3S94 3SOB 3SOQ 3SOV 4A0P 4DG6
Enriched GO Terms of Interacting Partners?		Response To Organonitrogen Compound Response To Organic Cyclic Compound Negative Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Embryo Development Negative Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Proliferation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Cell Death Negative Regulation Of Muscle Organ Development Negative Regulation Of Cell Cycle Regulation Of Cardiac Muscle Tissue Development Cellular Response To Organic Substance Embryonic Digit Morphogenesis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Odontogenesis Of Dentin-containing Tooth Response To Amino Acid Response To Organic Substance Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cell Proliferation Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Apoptotic Process In Bone Marrow Regulation Of Response To DNA Damage Stimulus Odontogenesis Cardiocyte Differentiation Regulation Of Striated Muscle Tissue Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Response To Alkaloid Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Organelle Organization	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Forebrain Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Anterior/posterior Pattern Specification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of MAP Kinase Activity Segmentation Regulation Of Protein Metabolic Process Cellular Response To Stimulus Generation Of Neurons Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Dermatome Development Spemann Organizer Formation Negative Regulation Of Signal Transduction Neurogenesis Regulation Of Proteolysis Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Neuron Differentiation Negative Regulation Of Signaling Response To Organic Substance Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of Protein Metabolic Process Brain Development Cellular Response To Manganese Ion Chordate Embryonic Development Regulation Of Kinase Activity Embryo Development Ending In Birth Or Egg Hatching Head Development Multicellular Organismal Development Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity
Tagcloud ?			3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Difference) ?			3a 5a 7b 8b 9a avian axin2 branch branching canonical characterizes chick crosstalk dkk1 explants fgf fh535 gastrulation governed lrp5 morphogenesis pk115 player preserved recapitulates sfrp1 shh vertebrate wnt
Tagcloud (Intersection) ?