ARL6 and PROS1

		ARL6	PROS1
Description		ARF like GTPase 6	protein S
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Axonemal Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Membrane Coat Cell Projection Extracellular Exosome	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Targeting To Membrane Intracellular Protein Transport Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Protein Transport Wnt Signaling Pathway Vesicle-mediated Transport Cell Projection Organization Melanosome Transport Fat Cell Differentiation Protein Polymerization Cilium Assembly Protein Localization To Cilium Protein Localization To Non-motile Cilium Protein Transport From Ciliary Membrane To Plasma Membrane	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		BBSome-mediated cargo-targeting to cilium	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade
Drugs			Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione
Diseases		Bardet-Biedl syndrome (BBS) Retinitis pigmentosa (RP)	Inherited thrombophilia
GWAS		Male infertility ( 19478329)	Systemic lupus erythematosus ( 28714469)
Interacting Genes		6 interacting genes: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	11 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3 VWF
Entrez ID		84100	5627
HPRD ID		10588	01473
Ensembl ID		ENSG00000113966	ENSG00000184500
Uniprot IDs		Q9H0F7	A0A0S2Z4K3 A0A0S2Z4L3 P07225
PDB IDs		2H57	1Z6C
Enriched GO Terms of Interacting Partners?		Regulation Of L-glutamate Import Across Plasma Membrane Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Cellular Localization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Organization Negative Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Amine Transport	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation
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