ARL6 and ARL6IP4

Number of citations of the paper that reports this interaction (PMID 10508919)
7

Data Source:
HPRD (two hybrid)

		ARL6	ARL6IP4
Gene Name		ADP-ribosylation factor-like 6	ADP-ribosylation factor-like 6 interacting protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat BBSome Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Nucleus Nucleolus Nuclear Speck
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Targeting To Membrane Organelle Organization Small GTPase Mediated Signal Transduction Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Melanosome Transport Cilium Assembly Fat Cell Differentiation Intermembrane Transport Protein Polymerization Protein Localization To Cilium	MRNA Processing RNA Splicing
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Male infertility ( 19478329)
Protein-Protein Interactions		6 interactors: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	11 interactors: ARL6 CSNK2A1 ETS1 FOS IKBKG RBM39 RNF41 SRPK1 SRPK2 SRSF11 THAP1
Entrez ID		84100	51329
HPRD ID		10588	09640
Ensembl ID		ENSG00000113966	ENSG00000182196
Uniprot IDs		Q9H0F7	B3V0L0 B3V0L1 Q66PJ3
PDB IDs		2H57
Enriched GO Terms of Interacting Partners?		Cotranslational Protein Targeting To Membrane Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Negative Regulation Of Mitochondrial Membrane Potential Retrograde Protein Transport, ER To Cytosol	RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Nucleus Organization Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process MRNA Processing Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Viral Genome Replication Regulation Of Myeloid Cell Differentiation Nitrogen Compound Metabolic Process MRNA Metabolic Process RNA Processing Immune Response Negative Regulation Of Viral Genome Replication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of MRNA Splicing, Via Spliceosome MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Viral Genome Replication Nuclear Speck Organization MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Viral Process Negative Regulation Of Viral Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cell Cycle Toll-like Receptor 4 Signaling Pathway Regulation Of MRNA Processing Regulation Of Metabolic Process Phosphorylation Intracellular Signal Transduction Intermembrane Transport Regulation Of RNA Splicing Cellular Response To Reactive Oxygen Species
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