ARL6 and SEC61B

Number of citations of the paper that reports this interaction (PMID 10508919)
7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARL6	SEC61B
Gene Name		ADP-ribosylation factor-like 6	Sec61 beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat BBSome Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Endoplasmic Reticulum Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding	Protein Binding Poly(A) RNA Binding Epidermal Growth Factor Binding
	Biological Process	Protein Targeting To Membrane Organelle Organization Small GTPase Mediated Signal Transduction Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Melanosome Transport Cilium Assembly Fat Cell Differentiation Intermembrane Transport Protein Polymerization Protein Localization To Cilium	Protein Import Into Nucleus, Translocation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Translation SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cellular Protein Metabolic Process
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium	Translation SRP-dependent cotranslational protein targeting to membrane Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Male infertility ( 19478329)
Protein-Protein Interactions		6 interactors: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	12 interactors: APOB ARL6 ASNA1 ATP13A2 BAG6 GET4 SEC63 SERP1 SPC25 TRAM1 UBC UBL4A
Entrez ID		84100	10952
HPRD ID		10588	06715
Ensembl ID		ENSG00000113966	ENSG00000106803
Uniprot IDs		Q9H0F7	P60468
PDB IDs		2H57
Enriched GO Terms of Interacting Partners?		Cotranslational Protein Targeting To Membrane Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Negative Regulation Of Mitochondrial Membrane Potential Retrograde Protein Transport, ER To Cytosol	Establishment Of Protein Localization To Membrane Membrane Organization Protein Localization To Membrane Protein Insertion Into ER Membrane Protein Localization To Organelle Establishment Of Protein Localization Protein Insertion Into Membrane Protein Localization Tail-anchored Membrane Protein Insertion Into ER Membrane Endoplasmic Reticulum Organization Transport Cellular Protein Localization Cellular Localization Protein Targeting To Membrane Endomembrane System Organization SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum Protein Targeting Multicellular Organismal Aging Organelle Organization Posttranslational Protein Targeting To Membrane, Translocation Intracellular Transport Establishment Of Protein Localization To Organelle Intracellular Protein Transport Intermembrane Transport Signal Transduction By P53 Class Mediator Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Establishment Of Localization In Cell Protein Acetylation Post-embryonic Development Glucose Metabolic Process Receptor Transactivation Cellular Response To Manganese Ion Response To Endoplasmic Reticulum Stress Posttranslational Protein Targeting To Membrane Mammary Gland Branching Involved In Thelarche Protein Catabolic Process Response To Selenium Ion Positive Regulation Of Growth Hormone Secretion Very-low-density Lipoprotein Particle Assembly Intracellular Receptor Signaling Pathway Cytoplasmic Transport Regulation Of Insulin Secretion Triglyceride Mobilization
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