ARL6 and ARL6IP6

Number of citations of the paper that reports this interaction (PMID 10508919)
7

Data Source:
HPRD (two hybrid)

		ARL6	ARL6IP6
Gene Name		ADP-ribosylation factor-like 6	ADP-ribosylation factor-like 6 interacting protein 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Axonemal Microtubule Plasma Membrane Cilium Axoneme Membrane Membrane Coat BBSome Ciliary Membrane Extracellular Vesicular Exosome Primary Cilium	Integral Component Of Membrane
	Molecular Function	Protein Binding GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Protein Targeting To Membrane Organelle Organization Small GTPase Mediated Signal Transduction Determination Of Left/right Symmetry Brain Development Visual Perception Regulation Of Smoothened Signaling Pathway Retina Layer Formation Wnt Signaling Pathway Melanosome Transport Cilium Assembly Fat Cell Differentiation Intermembrane Transport Protein Polymerization Protein Localization To Cilium
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Male infertility ( 19478329)
Protein-Protein Interactions		6 interactors: ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ATL2 SEC61B	2 interactors: APP ARL6
Entrez ID		84100	151188
HPRD ID		10588	12485
Ensembl ID		ENSG00000113966	ENSG00000177917
Uniprot IDs		Q9H0F7	B3KMZ5 Q8N6S5
PDB IDs		2H57
Enriched GO Terms of Interacting Partners?		Cotranslational Protein Targeting To Membrane Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Negative Regulation Of Mitochondrial Membrane Potential Retrograde Protein Transport, ER To Cytosol	Intermembrane Transport Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Brain Development Protein Localization To Cilium Head Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Copper Ion Homeostasis Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Cell Morphogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Retina Layer Formation Cell Projection Organization Neurological System Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Melanosome Transport Endoplasmic Reticulum Calcium Ion Homeostasis Pigment Granule Transport RNA Polyadenylation Neuron Recognition Establishment Of Melanosome Localization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Melanosome Localization Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Intracellular Transport Axon Cargo Transport Mating Neuromuscular Junction Development Neural Retina Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Retina Morphogenesis In Camera-type Eye Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Pigmentation Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway
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