PROS1 and RPSA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PROS1	RPSA
Gene Name		protein S (alpha)	ribosomal protein SA
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytosolic Small Ribosomal Subunit 90S Preribosome Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding Poly(A) RNA Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Endopeptidase Activity Peptidyl-glutamic Acid Carboxylation Platelet Activation Regulation Of Complement Activation Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Leukocyte Migration	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Export From Nucleus Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Cell Adhesion Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		Post-translational protein modification Platelet degranulation Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Cell surface interactions at the vascular wall Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Regulation of Complement cascade Complement cascade Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet activation, signaling and aggregation Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Innate Immune System	Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS
Protein-Protein Interactions		10 interactors: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	27 interactors: ABCD1 ACADVL ACD ANKH C6orf106 CALM2 CBX5 CLEC4G CSF2RA DCTN6 GNMT HBG2 HNRNPD IL7R ITGA6 KARS LAMA2 NKX3-1 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3
Entrez ID		5627	3921
HPRD ID		01473	01038
Ensembl ID		ENSG00000184500	ENSG00000168028
Uniprot IDs		P07225	P08865
PDB IDs		1Z6C	3BCH 3J3A
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Protein Activation Cascade Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Regulation Of Opsonization Response To Stress Protein Metabolic Process Platelet Activation Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cell Activation Negative Regulation Of Immune Response Negative Regulation Of Complement Activation Post-translational Protein Modification Immune System Process Regulation Of Complement Activation Negative Regulation Of Adaptive Immune Response Defense Response Acute-phase Response Regulation Of Inflammatory Response Regulation Of Humoral Immune Response Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Immune Response Negative Regulation Of Wound Healing Regulation Of Phagocytosis Platelet Degranulation Negative Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Negative Regulation Of Immune System Process Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Response To Stimulus Regulation Of Protein Processing Inflammatory Response Regulation Of Blood Coagulation RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Secretion By Cell Positive Regulation Of Protein Metabolic Process Regulation Of Wound Healing Complement Activation, Classical Pathway Regulation Of Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Fatty Acid Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of DNA Replication Wound Healing Negative Regulation Of Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Cellular Response To Organic Substance Telomere Maintenance Via Telomere Lengthening Regulation Of Fatty Acid Biosynthetic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein ADP-ribosylation Lysyl-tRNA Aminoacylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Peroxisomal Long-chain Fatty Acid Import Fructose Transport Regulation Of DNA Biosynthetic Process Fatty Acid Beta-oxidation Regulation Of Chromosome Organization Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Glycogen Metabolic Process Response To Stress Regulation Of Protein ADP-ribosylation Inorganic Diphosphate Transport Positive Regulation Of Androgen Secretion Interleukin-7-mediated Signaling Pathway
Tagcloud ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna
Tagcloud (Difference) ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna
Tagcloud (Intersection) ?