PROS1 and C4BPA

Number of citations of the paper that reports this interaction (PubMedID 1833851)
0

Data Source:
HPRD (in vitro, in vivo)

		PROS1	C4BPA
Description		protein S	complement component 4 binding protein alpha
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Response To Symbiotic Bacterium Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Immune Response Response To Other Organism Regulation Of Opsonization
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Systemic lupus erythematosus ( 28714469)	Bell's palsy ( 33602968) C4b binding protein levels ( 20212171) Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		11 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3 VWF	11 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I HSP90AA1 LBP LRP1 PROS1 SMARCD1 TXN
Entrez ID		5627	722
HPRD ID		01473	00403
Ensembl ID		ENSG00000184500	ENSG00000123838
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	P04003
PDB IDs		1Z6C	2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q 8TCB 8TGT
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation	Chaperone-mediated Protein Complex Assembly Regulation Of Multicellular Organismal Process Acute-phase Response Negative Regulation Of Wound Healing Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Multicellular Organismal Process Acute Inflammatory Response Regulation Of SMAD Protein Signal Transduction Artery Morphogenesis Clathrin-coated Pit Protein Tyrosine Kinase Binding Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Regulation Of Transcytosis Apolipoprotein Receptor Activity Cellular Detoxification Of Hydrogen Peroxide Blood Vessel Morphogenesis Activin Receptor Activity, Type II Rho GDP-dissociation Inhibitor Binding Lipoprotein Particle Receptor Binding Detoxification Of Hydrogen Peroxide Negative Regulation Of Developmental Process Unfolded Protein Binding Regulation Of Lung Blood Pressure Positive Regulation Of Multicellular Organismal Process Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Nucleocytoplasmic Transport Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-disulfide Reductase [NAD(P)H] Activity Blood Microparticle
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