PROS1 and F8

Number of citations of the paper that reports this interaction (PMID 7620160)
6

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PROS1	F8
Gene Name		protein S (alpha)	coagulation factor VIII, procoagulant component
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Platelet Alpha Granule Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Endopeptidase Activity Peptidyl-glutamic Acid Carboxylation Platelet Activation Regulation Of Complement Activation Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Leukocyte Migration	Platelet Degranulation Proteolysis Acute-phase Response Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Oxidation-reduction Process
Pathways		Post-translational protein modification Platelet degranulation Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Cell surface interactions at the vascular wall Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Regulation of Complement cascade Complement cascade Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet activation, signaling and aggregation Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Innate Immune System	Common Pathway Intrinsic Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate	Drotrecogin alfa Coagulation Factor IX
Diseases
GWAS			Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Red blood cell traits ( 23446634)
Protein-Protein Interactions		10 interactors: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	16 interactors: ASGR2 CALR CANX F10 F2 F9 GGA1 HSPA5 LMAN1 LRP1 MCFD2 PHYH PROC PROS1 UBQLN1 VWF
Entrez ID		5627	2157
HPRD ID		01473	02384
Ensembl ID		ENSG00000184500	ENSG00000185010
Uniprot IDs		P07225	P00451
PDB IDs		1Z6C	1CFG 1D7P 1FAC 1IQD 2R7E 3CDZ 3HNB 3HNY 3HOB 3J2Q 3J2S 4BDV
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Protein Activation Cascade Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Regulation Of Opsonization Response To Stress Protein Metabolic Process Platelet Activation Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cell Activation Negative Regulation Of Immune Response Negative Regulation Of Complement Activation Post-translational Protein Modification Immune System Process Regulation Of Complement Activation Negative Regulation Of Adaptive Immune Response Defense Response Acute-phase Response Regulation Of Inflammatory Response Regulation Of Humoral Immune Response Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Immune Response Negative Regulation Of Wound Healing Regulation Of Phagocytosis Platelet Degranulation Negative Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Negative Regulation Of Immune System Process Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Response To Stimulus Regulation Of Protein Processing Inflammatory Response Regulation Of Blood Coagulation RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Secretion By Cell Positive Regulation Of Protein Metabolic Process Regulation Of Wound Healing Complement Activation, Classical Pathway Regulation Of Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin	Post-translational Protein Modification Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Regulation Of Body Fluid Levels Wound Healing Peptidyl-amino Acid Modification Vesicle-mediated Transport Response To Wounding Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Protein Metabolic Process Blood Coagulation, Extrinsic Pathway Protein Activation Cascade Negative Regulation Of Blood Coagulation Platelet Activation Negative Regulation Of Coagulation Glycoprotein Metabolic Process Negative Regulation Of Wound Healing Response To Stress Platelet Degranulation Regulation Of Blood Coagulation Protein Glycosylation Macromolecule Glycosylation Glycosylation Cellular Protein Modification Process Receptor-mediated Endocytosis Regulation Of Wound Healing Cellular Protein Metabolic Process Glycoprotein Biosynthetic Process Establishment Of Localization In Cell Response To Endoplasmic Reticulum Stress Fibrinolysis Secretion By Cell Proteolysis Transport Leukocyte Migration Cellular Localization Regulation Of Cell Migration Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of Cell Motility Chaperone-mediated Protein Folding Secretion Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Endocytosis
Tagcloud ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Difference) ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	absent ba betac csf f3 gm gmr gmralpha gmrbeta granulocyte heterodimeric magnitude mitogenesis next phenylalanine phosphorylaiton proliferate prominent regenerate residues restored shc shp2 stat5 sufficient tyrosine y577 y612 y695
Tagcloud (Intersection) ?