PROS1 and C4BPB

Number of citations of the paper that reports this interaction (PMID 12492479)
1

Data Source:
HPRD (in vitro)

		PROS1	C4BPB
Gene Name		protein S (alpha)	complement component 4 binding protein, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Other Organism Cell
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Protein Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Endopeptidase Activity Peptidyl-glutamic Acid Carboxylation Platelet Activation Regulation Of Complement Activation Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Leukocyte Migration	Complement Activation, Classical Pathway Blood Coagulation Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Post-translational protein modification Platelet degranulation Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Cell surface interactions at the vascular wall Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Regulation of Complement cascade Complement cascade Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet activation, signaling and aggregation Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS			C4b binding protein levels ( 20212171)
Protein-Protein Interactions		10 interactors: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	1 interactors: PROS1
Entrez ID		5627	725
HPRD ID		01473	00404
Ensembl ID		ENSG00000184500	ENSG00000123843
Uniprot IDs		P07225	P20851
PDB IDs		1Z6C
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Protein Activation Cascade Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Regulation Of Opsonization Response To Stress Protein Metabolic Process Platelet Activation Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cell Activation Negative Regulation Of Immune Response Negative Regulation Of Complement Activation Post-translational Protein Modification Immune System Process Regulation Of Complement Activation Negative Regulation Of Adaptive Immune Response Defense Response Acute-phase Response Regulation Of Inflammatory Response Regulation Of Humoral Immune Response Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Immune Response Negative Regulation Of Wound Healing Regulation Of Phagocytosis Platelet Degranulation Negative Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Negative Regulation Of Immune System Process Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Response To Stimulus Regulation Of Protein Processing Inflammatory Response Regulation Of Blood Coagulation RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Secretion By Cell Positive Regulation Of Protein Metabolic Process Regulation Of Wound Healing Complement Activation, Classical Pathway Regulation Of Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin	Peptidyl-glutamic Acid Carboxylation Fibrinolysis Regulation Of Complement Activation Regulation Of Humoral Immune Response Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Acute Inflammatory Response Regulation Of Blood Coagulation Regulation Of Wound Healing Platelet Activation Post-translational Protein Modification Leukocyte Migration Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Inflammatory Response Exocytosis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis
Tagcloud ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	1q assigned assignments chromosome coagulation corresponds f5 glucocorticoid gr homologous hybrids lca leukocyte linkage make mapping maps mbp message myelin portion renin repressed somatic substantial testosterone trpm2 utilized
Tagcloud (Difference) ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	1q assigned assignments chromosome coagulation corresponds f5 glucocorticoid gr hybrids lca leukocyte linkage make mapping maps mbp message myelin portion renin repressed somatic substantial testosterone trpm2 utilized
Tagcloud (Intersection) ?		homologous