PROS1 and PROC

Number of citations of the paper that reports this interaction (PMID 2461936)
8

Data Source:
HPRD (in vitro)

		PROS1	PROC
Gene Name		protein S (alpha)	protein C (inactivator of coagulation factors Va and VIIIa)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Endopeptidase Activity Peptidyl-glutamic Acid Carboxylation Platelet Activation Regulation Of Complement Activation Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Leukocyte Migration	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Post-translational protein modification Platelet degranulation Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Cell surface interactions at the vascular wall Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Regulation of Complement cascade Complement cascade Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet activation, signaling and aggregation Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Innate Immune System	Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate	Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS			Protein C levels ( 20802025)
Protein-Protein Interactions		10 interactors: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		5627	5624
HPRD ID		01473	01466
Ensembl ID		ENSG00000184500	ENSG00000115718
Uniprot IDs		P07225	B4DPQ7 P04070
PDB IDs		1Z6C	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Protein Activation Cascade Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Regulation Of Opsonization Response To Stress Protein Metabolic Process Platelet Activation Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cell Activation Negative Regulation Of Immune Response Negative Regulation Of Complement Activation Post-translational Protein Modification Immune System Process Regulation Of Complement Activation Negative Regulation Of Adaptive Immune Response Defense Response Acute-phase Response Regulation Of Inflammatory Response Regulation Of Humoral Immune Response Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Immune Response Negative Regulation Of Wound Healing Regulation Of Phagocytosis Platelet Degranulation Negative Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Negative Regulation Of Immune System Process Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Response To Stimulus Regulation Of Protein Processing Inflammatory Response Regulation Of Blood Coagulation RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Secretion By Cell Positive Regulation Of Protein Metabolic Process Regulation Of Wound Healing Complement Activation, Classical Pathway Regulation Of Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity
Tagcloud ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Difference) ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Intersection) ?