PROS1 and PROC

Number of citations of the paper that reports this interaction (PubMedID 2461936)
0

Data Source:
HPRD (in vitro)

		PROS1	PROC
Description		protein S	protein C, inactivator of coagulation factors Va and VIIIa
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		Inherited thrombophilia	Inherited thrombophilia
GWAS		Systemic lupus erythematosus ( 28714469)	Blood protein levels ( 30072576) Protein C levels ( 20802025 25376901 28082259)
Interacting Genes		11 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3 VWF	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		5627	5624
HPRD ID		01473	01466
Ensembl ID		ENSG00000184500	ENSG00000115718
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	B4DPC8 B4DPQ3 E7END6 P04070
PDB IDs		1Z6C	1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex
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