PROS1 and F5

Number of citations of the paper that reports this interaction (PMID 8428962)
33

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		PROS1	F5
Gene Name		protein S (alpha)	coagulation factor V (proaccelerin, labile factor)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Platelet Alpha Granule Lumen Vesicle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Negative Regulation Of Endopeptidase Activity Peptidyl-glutamic Acid Carboxylation Platelet Activation Regulation Of Complement Activation Fibrinolysis Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Leukocyte Migration	Platelet Degranulation Proteolysis Blood Coagulation Blood Circulation Platelet Activation
Pathways		Post-translational protein modification Platelet degranulation Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Cell surface interactions at the vascular wall Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Regulation of Complement cascade Complement cascade Response to elevated platelet cytosolic Ca2+ Removal of aminoterminal propeptides from gamma-carboxylated proteins Platelet activation, signaling and aggregation Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Innate Immune System	Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Drotrecogin alfa Menadione Sodium Tetradecyl Sulfate	Drotrecogin alfa Phenylmercury
Diseases
GWAS			Activated partial thromboplastin time ( 22703881) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 22672568)
Protein-Protein Interactions		10 interactors: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	10 interactors: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3
Entrez ID		5627	2153
HPRD ID		01473	01964
Ensembl ID		ENSG00000184500
Uniprot IDs		P07225	P12259
PDB IDs		1Z6C	1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Protein Activation Cascade Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Intrinsic Pathway Regulation Of Opsonization Response To Stress Protein Metabolic Process Platelet Activation Negative Regulation Of Complement Activation, Classical Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cell Activation Negative Regulation Of Immune Response Negative Regulation Of Complement Activation Post-translational Protein Modification Immune System Process Regulation Of Complement Activation Negative Regulation Of Adaptive Immune Response Defense Response Acute-phase Response Regulation Of Inflammatory Response Regulation Of Humoral Immune Response Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Immune Response Negative Regulation Of Wound Healing Regulation Of Phagocytosis Platelet Degranulation Negative Regulation Of Protein Processing Regulation Of Acute Inflammatory Response Negative Regulation Of Immune System Process Peptidyl-amino Acid Modification Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Acute Inflammatory Response Response To Stimulus Regulation Of Protein Processing Inflammatory Response Regulation Of Blood Coagulation RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Secretion By Cell Positive Regulation Of Protein Metabolic Process Regulation Of Wound Healing Complement Activation, Classical Pathway Regulation Of Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin	Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Response To Stress Blood Coagulation Hemostasis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Leukocyte Migration Negative Regulation Of Coagulation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Wound Healing Acute Inflammatory Response Killing By Host Of Symbiont Cells Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Processing Proteolysis Regulation Of Protein Processing Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Peptidyl-amino Acid Modification Response To Stimulus Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Platelet Activation Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Locomotion Interaction With Symbiont Leukocyte Mediated Cytotoxicity Immune System Process Defense Response Regulation Of Proteolysis Acute-phase Response Response To Fungus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Movement Of Cell Or Subcellular Component Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Protein Metabolic Process Positive Regulation Of Cell Proliferation
Tagcloud ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy
Tagcloud (Difference) ?		acs axl bridging carboxylation chimeric differentially diversity enveloped fact gas6 homologous immunity immunoglobulin immunoregulation ligands mer opsonize perform phosphatidylserine ps share similarity soluble suppressing tam tams turn tyro3 vesicles	alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy
Tagcloud (Intersection) ?