PROS1 and F5

Number of citations: 0 (PubMedID 10593904)
Data Source: BioGRID (pull down, pull down), HPRD (in vitro)

		PROS1	F5
Name		protein S	coagulation factor V
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	Copper Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Blood Coagulation Hemostasis Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases		Inherited thrombophilia	Factor V deficiency; Owren disease Inherited thrombophilia
GWAS		Systemic lupus erythematosus ( 28714469 )	Activated partial thromboplastin time ( 22703881 29403010 ) Cytokine network levels (multivariate analysis) ( 31679650 ) D-dimer levels ( 21502573 ) D-dimer levels in HIV infection ( 33095540 ) Hemostatic factors and hematological phenotypes ( 22443383 ) Hippocampal atrophy ( 22745009 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Ischemic stroke ( 26732560 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Medication use (antithrombotic agents) ( 31015401 ) Optic disc area ( 31798171 25631615 ) Optic disc size ( 31809533 ) Peripheral artery disease ( 31285632 ) Plasma factor V levels in venous thrombosis ( 31271701 ) Prothrombin time ( 29403010 ) Stem cell growth factor beta levels ( 27989323 ) Thrombosis ( 26908601 ) Uric acid levels ( 23703922 ) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494 ) Vertical cup-disc ratio ( 31798171 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Novel Interactors		2 novel interactors: ARL6 HSP90AB1	2 novel interactors: FCER1G FCGR2A
Interacting Genes		11 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3 VWF	11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
Entrez ID		5627	2153
HPRD ID		01473	01964
Ensembl ID		ENSG00000184500	ENSG00000198734
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	P12259
PDB IDs		1Z6C	1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH
GO Terms Enriched among Interactors		Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Golgi Lumen Endoplasmic Reticulum Lumen Extracellular Region Extracellular Space Response To Symbiotic Bacterium Response To Symbiont Negative Regulation Of Complement Activation, Classical Pathway Platelet Activation Platelet Alpha Granule Lumen Regulation Of Opsonization Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Complement Activation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Platelet Alpha Granule Serine-type Peptidase Activity Regulation Of Complement Activation Defense Response To Symbiont Defense Response To Other Organism Immune Effector Process Regulation Of Biological Quality Serine-type Endopeptidase Activity Plasma Membrane Biological Process Involved In Interaction With Host Defense Response Complement Activation, Classical Pathway COPII-coated ER To Golgi Transport Vesicle Acute-phase Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Immune Response Regulation Of Humoral Immune Response Positive Regulation Of Signal Transduction Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Copper Ion Binding Response To Stress Negative Regulation Of Coagulation Complement Activation Humoral Immune Response Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Acute Inflammatory Response Innate Immune Response Positive Regulation Of Cell Communication Cell Activation Positive Regulation Of Signaling Regulation Of Blood Coagulation	Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process