SEC61B and MUTYH

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SEC61B	MUTYH
Description		SEC61 translocon subunit beta	mutY DNA glycosylase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA Binding Catalytic Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway	DNA Repair Base-excision Repair Mismatch Repair Response To Stress DNA Damage Response Depurination Negative Regulation Of Necroptotic Process
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases			Familial adenomatous polyposis
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Composite immunoglobulin trait (IgA/IgM) ( 28628107) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1	19 interacting genes: AGTRAP APEX1 BAAT CYLC2 FANCC HRAS LMNA LRSAM1 MSANTD3 MSH6 PCNA RPA1 RPA4 SEC61B SIRT6 SMAD1 TDRD7 TSTD2 XPA
Entrez ID		10952	4595
HPRD ID		06715	05380
Ensembl ID		ENSG00000106803	ENSG00000132781
Uniprot IDs		P60468	A0AAQ5BGW7 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 E9PP34 Q9UIF7
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8	1X51 3N5N 8FAY
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization	Damaged DNA Binding Base-excision Repair DNA Repair Nucleotide-excision Repair DNA Replication Factor A Complex DNA Metabolic Process DNA Damage Response Chromosome, Telomeric Region Cellular Response To Stress Mismatch Repair Site Of Double-strand Break Response To Stress Response To UV MutLalpha Complex Binding Male Germ Cell Nucleus Chromosome Organization Nuclear Lamina Base-excision Repair, Gap-filling Response To Radiation DNA Recombination Telomere Maintenance Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Telomere Organization Protein Localization To Site Of Double-strand Break Response To Light Stimulus DNA Replication Protein Localization To Organelle Determination Of Adult Lifespan Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Glycine N-choloyltransferase Activity Bile Acid Conjugation Meiotic Mismatch Repair Intrinsic Apoptotic Signaling Pathway Cellular Response To Radiation Protein Localization To Nucleus PCNA Complex Replisome Site Of DNA Damage Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Sec Complex Histone H3K56 Deacetylase Activity, NAD-dependent Negative Regulation Of Cell Population Proliferation DNA-(abasic Site) Binding Nucleoplasm Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity
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