SEC61B and APOB

Number of citations of the paper that reports this interaction (PubMedID 9565615)
0

Data Source:
HPRD (in vivo)

		SEC61B	APOB
Description		SEC61 translocon subunit beta	apolipoprotein B
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GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Non-HDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817) Triglyceride levels ( 29403010 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1	25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2
Entrez ID		10952	338
HPRD ID		06715	00133
Ensembl ID		ENSG00000106803	ENSG00000084674
Uniprot IDs		P60468	A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8	9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization	Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death
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