SEC61B and SPC25

Number of citations of the paper that reports this interaction (PubMedID 9585408)
21

Data Source:
HPRD (in vivo)

		SEC61B	SPC25
Description		SEC61 translocon subunit beta	SPC25 component of NDC80 kinetochore complex
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Chromosome Cytosol Ndc80 Complex
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Ribosome Binding Epidermal Growth Factor Binding	Protein Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Protein Transport Retrograde Protein Transport, ER To Cytosol Post-translational Protein Targeting To Membrane, Translocation ERAD Pathway	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Fasting blood glucose ( 29621232) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 34059833) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CALM1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1	3 interacting genes: HGS NDC80 SEC61B
Entrez ID		10952	57405
HPRD ID		06715	15465
Ensembl ID		ENSG00000106803	ENSG00000152253
Uniprot IDs		P60468	Q9HBM1
PDB IDs		6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3 8OJ0 8OJ8	2VE7 3IZ0 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Protein Targeting To Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Insertion Into Membrane Regulation Of Protein Stability Protein Targeting BAT3 Complex Protein Targeting To ER Establishment Of Protein Localization Maintenance Of Unfolded Protein Establishment Of Protein Localization To Endoplasmic Reticulum Localization Within Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Carrier Chaperone Intracellular Protein Localization Nucleoplasm Post-embryonic Development Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Protein Stabilization Cotranslational Protein Targeting To Membrane Regulation Of Mitotic Cell Cycle Outer Kinetochore Cellular Response To Stress Response To Stress Synaptonemal Complex Assembly Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Nuclear Division Synaptonemal Complex Organization Negative Regulation Of Protein Catabolic Process Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Signaling Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Negative Regulation Of Proteolysis Mismatch Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Intracellular Protein Transmembrane Transport Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Phase Transition Negative Regulation Of Epithelial Cell Proliferation Mature Chylomicron Lipid Homeostasis Cellular Localization	ESCRT-0 Complex Phagocytic Vesicle Lumen Establishment Of Localization In Cell Meiotic Cell Cycle Phase Transition Ndc80 Complex G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Spindle Assembly Involved In Female Meiosis I Epidermal Growth Factor Binding Endoplasmic Reticulum Sec Complex Skeletal Muscle Satellite Cell Proliferation Sec61 Translocon Complex Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Membrane Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Multivesicular Body Organization Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Targeting To Lysosome Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Exosomal Secretion Ubiquitin-like Protein Ligase Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Multivesicular Body Assembly Negative Regulation Of Receptor Signaling Pathway Via STAT Organelle Assembly Intracellular Protein Transport Positive Regulation Of Exosomal Secretion Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Skeletal Muscle Cell Proliferation Cyclin Binding Outer Kinetochore Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Meiotic Spindle Organization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Centrosome Duplication Kinetochore Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Checkpoint Intracellular Protein Transmembrane Transport Retrograde Protein Transport, ER To Cytosol SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Quality Control Compartment Late Endosome To Vacuole Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?