BRIP1 and BARD1

Number of citations of the paper that reports this interaction (PMID 20451671)
2

Data Source:
BioGRID (unspecified method)

		BRIP1	BARD1
Gene Name		BRCA1 interacting protein C-terminal helicase 1	BRCA1 associated RING domain 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm BRCA1-BARD1 Complex Intracellular Membrane-bounded Organelle BRCA1-A Complex
	Molecular Function	DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding Small Molecule Metabolic Process	Tissue Homeostasis DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination
Pathways		Homologous DNA pairing and strand exchange Cytosolic iron-sulfur cluster assembly Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS			Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175)
Protein-Protein Interactions		6 interactors: BARD1 BLM BRCA1 HNRNPC RPA1 TOPBP1	107 interactors: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 BRIP1 CAP1 CASC1 CCDC136 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CRIPAK CSTF1 DCC DDX39B EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AFX HAP1 HIST2H2AC HNRNPC HNRNPLL HSPA14 IDI1 IKBKAP ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS3 LGALS8 LRIF1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT2A ND1 NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 XRCC6 ZFP64 ZHX1 ZNF121
Entrez ID		83990	580
HPRD ID		05797	03354
Ensembl ID			ENSG00000138376
Uniprot IDs		Q9BX63	Q99728
PDB IDs		1T29 3AL3	1JM7 2NTE 2R1Z 3C5R 3FA2
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Protein K6-linked Ubiquitination Response To Ionizing Radiation Double-strand Break Repair Cellular Response To Stress DNA Recombination DNA Replication G2 DNA Damage Checkpoint Cell Cycle Process Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cell Cycle Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA-dependent DNA Replication Response To Stress Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation DNA Catabolic Process DNA Damage Checkpoint Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Camptothecin Cellular Response To Hydroxyurea Protein Polyubiquitination Tissue Homeostasis Response To Camptothecin Negative Regulation Of Mitotic Recombination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle DNA Recombinase Assembly Cellular Response To Indole-3-methanol Negative Regulation Of Cell Death Cell Cycle Checkpoint Negative Regulation Of Centriole Replication Regulation Of Mitotic Recombination Multicellular Organismal Homeostasis Chromosome Organization	Cellular Response To DNA Damage Stimulus DNA Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process Double-strand Break Repair DNA Metabolic Process Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Stress Cell Cycle Checkpoint DNA Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Meiotic Mismatch Repair Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Modification-dependent Protein Catabolic Process Chromatin Organization DNA Damage Checkpoint Cellular Macromolecule Catabolic Process Immune System Process Viral Process Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		alleles atm brca1 brca2 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		alleles atm brca1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	10ng agreed atr belonged biosynthetic biphenyls dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?		brca2