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BRIP1 and TOPBP1
Number of citations of the paper that reports this interaction (PubMedID
21127055
)
70
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology, proximity labelling technology, affinity chromatography technology)
BRIP1
TOPBP1
Description
BRCA1 interacting DNA helicase 1
DNA topoisomerase II binding protein 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Nuclear Membrane
BRCA1-B Complex
Condensed Nuclear Chromosome
Spindle Pole
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Nuclear Body
PML Body
Site Of Double-strand Break
BRCA1-B Complex
Site Of DNA Damage
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
5'-3' DNA Helicase Activity
Metal Ion Binding
Iron-sulfur Cluster Binding
4 Iron, 4 Sulfur Cluster Binding
Catalytic Activity, Acting On A Nucleic Acid
DNA Binding
Protein Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Phosphorylation-dependent Protein Binding
Chromatin-protein Adaptor Activity
Biological Process
DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Spermatogonial Cell Division
Spermatid Development
Male Gonad Development
Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination
Homologous Recombination
Interstrand Cross-link Repair
Chiasma Assembly
Seminiferous Tubule Development
Protein-DNA Covalent Cross-linking Repair
Double-strand Break Repair Involved In Meiotic Recombination
DNA Replication Checkpoint Signaling
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Metabolic Process
DNA Replication Initiation
DNA Repair
Double-strand Break Repair
Chromatin Organization
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To Ionizing Radiation
Mitotic DNA Replication Checkpoint Signaling
Homologous Recombination
Chromosome Organization
Double-strand Break Repair Via Classical Nonhomologous End Joining
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Broken Chromosome Clustering
Protein Localization To Site Of Double-strand Break
Pathways
Cytosolic iron-sulfur cluster assembly
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Diseases
Fanconi anemia
GWAS
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Ovarian cancer (
21964575
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Iron status biomarkers (
19084217
)
Interacting Genes
10 interacting genes:
BLM
BRCA1
CREBBP
FANCD2
HDAC3
HNRNPC
HSD17B14
RPA1
SIRT1
TOPBP1
30 interacting genes:
ABL1
AKT1
ATM
BMPR2
BRIP1
CDC45
CHEK1
CIP2A
CLSTN1
E2F1
ESR1
GINS1
HUS1
NFYA
PML
POLE
PPHLN1
PPP1CC
RAD1
RAD9A
RAI1
RBBP8
SMARCAD1
TBC1D4
TCFL5
TEX11
TOP2B
UBR5
USP13
ZBTB17
Entrez ID
83990
11073
HPRD ID
05797
09678
Ensembl ID
ENSG00000136492
ENSG00000163781
Uniprot IDs
A0A804HJU1
A0A804HL36
J3QKX0
Q9BX63
A0A2R8YD63
A0AV47
A7E2X7
Q05BV8
Q92547
PDB IDs
1T15
1T29
3AL3
1WF6
2XNH
2XNK
3AL2
3AL3
3JVE
3OLC
3PD7
3UEN
3UEO
6RML
6RMM
7CMZ
8OK2
Enriched GO Terms of Interacting Partners
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Recombinational Repair
Double-strand Break Repair
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Response To Ionizing Radiation
Male Germ Cell Nucleus
Lateral Element
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
P53 Binding
DNA Metabolic Process
Response To Radiation
DNA Recombination
DNA Damage Response
DNA Damage Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
PML Body
Chromatin Organization
Negative Regulation Of Cell Cycle Process
Mitotic G2 DNA Damage Checkpoint Signaling
Condensed Chromosome
BRCA1-B Complex
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle
Condensed Nuclear Chromosome
Cellular Response To Radiation
Cellular Response To Stress
Mitotic G2/M Transition Checkpoint
Nucleoplasm
Damaged DNA Binding
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Cellular Response To Ionizing Radiation
Deacetylase Activity
Regulation Of DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Random Inactivation Of X Chromosome
Peptidyl-lysine Acetylation
Protein Deacetylation
Protein Lysine Deacetylase Activity
DNA Repair Complex
Regulation Of Cellular Response To Heat
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin-protein Adaptor Activity
Histone Deacetylase Activity
Regulation Of Cell Cycle
DNA Metabolic Process
Negative Regulation Of Cell Cycle
DNA Damage Response
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Cellular Response To Stress
Nucleoplasm
DNA Repair
Negative Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Chromosome
Macromolecule Metabolic Process
Checkpoint Clamp Complex
Negative Regulation Of Mitotic Cell Cycle
DNA Double-strand Break Processing
Intracellular Signal Transduction
Nucleus
Chromosome Organization
Regulation Of Mitotic Cell Cycle
Reproductive Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Cell Cycle Process
Homologous Recombination
Response To Stress
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Fibroblast Proliferation
Regulation Of Cellular Response To Stress
DNA Recombination
Cellular Senescence
DNA Replication Checkpoint Signaling
Regulation Of RNA Biosynthetic Process
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Cellular Response To Ionizing Radiation
Response To Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Developmental Process Involved In Reproduction
Regulation Of RNA Metabolic Process
Regulation Of Fibroblast Proliferation
Regulation Of DNA Metabolic Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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