BRIP1

Gene Name		BRCA1 interacting protein C-terminal helicase 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Membrane
	Molecular Function	DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Damage Checkpoint Double-strand Break Repair Regulation Of Transcription From RNA Polymerase II Promoter DNA Duplex Unwinding Small Molecule Metabolic Process
Pathways		Homologous DNA pairing and strand exchange Cytosolic iron-sulfur cluster assembly Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: BARD1 BLM BRCA1 HNRNPC RPA1 TOPBP1
Entrez ID		83990
HPRD ID		05797
Ensembl ID
Uniprot IDs		Q9BX63
PDB IDs		1T29 3AL3
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Metabolic Process Protein K6-linked Ubiquitination Response To Ionizing Radiation Double-strand Break Repair Cellular Response To Stress DNA Recombination DNA Replication G2 DNA Damage Checkpoint Cell Cycle Process Nucleobase-containing Compound Metabolic Process Response To Abiotic Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cell Cycle Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA-dependent DNA Replication Response To Stress Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation DNA Catabolic Process DNA Damage Checkpoint Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Camptothecin Cellular Response To Hydroxyurea Protein Polyubiquitination Tissue Homeostasis Response To Camptothecin Negative Regulation Of Mitotic Recombination Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle DNA Recombinase Assembly Cellular Response To Indole-3-methanol Negative Regulation Of Cell Death Cell Cycle Checkpoint Negative Regulation Of Centriole Replication Regulation Of Mitotic Recombination Multicellular Organismal Homeostasis Chromosome Organization
Tagcloud ?		alleles atm brca1 brca2 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue