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BRIP1
Gene Name
BRCA1 interacting protein C-terminal helicase 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Nuclear Membrane
Molecular Function
DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
DNA Damage Checkpoint
Double-strand Break Repair
Regulation Of Transcription From RNA Polymerase II Promoter
DNA Duplex Unwinding
Small Molecule Metabolic Process
Pathways
Homologous DNA pairing and strand exchange
Cytosolic iron-sulfur cluster assembly
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-protein Interactions
6 interactors:
BARD1
BLM
BRCA1
HNRNPC
RPA1
TOPBP1
Entrez ID
83990
HPRD ID
05797
Ensembl ID
Uniprot IDs
Q9BX63
PDB IDs
1T29
3AL3
Enriched GO Terms of Interacting Partners
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DNA Repair
Cellular Response To DNA Damage Stimulus
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
DNA Metabolic Process
Protein K6-linked Ubiquitination
Response To Ionizing Radiation
Double-strand Break Repair
Cellular Response To Stress
DNA Recombination
DNA Replication
G2 DNA Damage Checkpoint
Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Response To Abiotic Stimulus
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Radiation
Negative Regulation Of Cell Cycle
Cell Cycle
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
DNA-dependent DNA Replication
Response To Stress
Negative Regulation Of MRNA 3'-end Processing
Positive Regulation Of Histone H3-K9 Acetylation
DNA Catabolic Process
DNA Damage Checkpoint
Positive Regulation Of Histone H4 Acetylation
Negative Regulation Of Histone H3-K4 Methylation
Cellular Response To Camptothecin
Cellular Response To Hydroxyurea
Protein Polyubiquitination
Tissue Homeostasis
Response To Camptothecin
Negative Regulation Of Mitotic Recombination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Cycle
DNA Recombinase Assembly
Cellular Response To Indole-3-methanol
Negative Regulation Of Cell Death
Cell Cycle Checkpoint
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Recombination
Multicellular Organismal Homeostasis
Chromosome Organization
Tagcloud
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alleles
atm
brca1
brca2
cdh1
chek2
confer
contributing
contributive
fashion
hereditary
influences
lifetime
offers
otherwise
palb2
penetrance
penetrant
personal
polygenic
predisposing
predisposition
quite
snp
stk11
suggestive
suspicion
unlikely
venue