SPNS1 and CCR9

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SPNS1	CCR9
Description		SPNS lysolipid transporter 1, lysophospholipid	C-C motif chemokine receptor 9
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Lipid Transport Phospholipid Efflux Regulation Of Lysosomal Lumen PH Lysophospholipid Transport Transmembrane Transport	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Educational attainment ( 25201988)	Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		8 interacting genes: ADORA2A BCL2 BCL2L1 BDKRB2 CCR8 CCR9 CHRM5 HTR2C	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		83985	10803
HPRD ID		11599	09200
Ensembl ID		ENSG00000169682	ENSG00000173585
Uniprot IDs		Q9H2V7	B2R734 P51686
PDB IDs		9BOI	5LWE
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Dendritic Cell Apoptotic Process BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Defense Response Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Apoptotic Signaling Pathway Signal Transduction Regulation Of Biological Quality Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Anoikis Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Release Of Cytochrome C From Mitochondria Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Anoikis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Behavioral Fear Response Behavioral Defense Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phospholipid Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Channel Activity Fear Response Blood Circulation Regulation Of Neuron Apoptotic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Vascular Permeability Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Cellular Defense Response Response To Gamma Radiation Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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