SPNS1 and HTR2C

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SPNS1	HTR2C
Description		SPNS lysolipid transporter 1, lysophospholipid	5-hydroxytryptamine receptor 2C
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Membrane	Plasma Membrane Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Protein Binding Transmembrane Transporter Activity	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity
	Biological Process	Lipid Transport Phospholipid Efflux Regulation Of Lysosomal Lumen PH Lysophospholipid Transport Transmembrane Transport	Behavioral Fear Response Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways			Serotonin receptors G alpha (q) signalling events
Drugs			Tramadol Ziprasidone Methysergide Cabergoline Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Flupentixol Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Pimavanserin Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Nandrolone decanoate Captodiame Viloxazine Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Educational attainment ( 25201988)
Interacting Genes		8 interacting genes: ADORA2A BCL2 BCL2L1 BDKRB2 CCR8 CCR9 CHRM5 HTR2C	34 interacting genes: APBA1 ARLN ARRB2 ATP2B3 ATP6AP2 ATP6V0C CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SLC71A1 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1
Entrez ID		83985	3358
HPRD ID		11599	02429
Ensembl ID		ENSG00000169682	ENSG00000147246
Uniprot IDs		Q9H2V7	K9J958 P28335
PDB IDs		9BOI	6BQG 6BQH 8DPF 8DPG 8DPH 8DPI 8ZMF
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Dendritic Cell Apoptotic Process BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Defense Response Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Apoptotic Signaling Pathway Signal Transduction Regulation Of Biological Quality Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Anoikis Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Release Of Cytochrome C From Mitochondria Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Anoikis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Behavioral Fear Response Behavioral Defense Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phospholipid Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Channel Activity Fear Response Blood Circulation Regulation Of Neuron Apoptotic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Vascular Permeability Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Cellular Defense Response Response To Gamma Radiation Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Membrane Endoplasmic Reticulum Membrane Plasma Membrane Transmembrane Transport Cellular Homeostasis Intracellular Chemical Homeostasis Homeostatic Process Chemical Homeostasis Synapse Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Cation Transmembrane Transport Endoplasmic Reticulum PDZ Domain Binding Monoatomic Cation Transmembrane Transport Ubiquitin Protein Ligase Binding Monoatomic Cation Homeostasis Regulation Of Lysosomal Lumen PH Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Ion Transport D1 Dopamine Receptor Binding Monoatomic Cation Transport Glutamatergic Synapse Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Regulation Of Membrane Potential Neuron Cellular Homeostasis Glutamate Secretion Endosomal Lumen Acidification G Protein-coupled Receptor Binding Dystrophin-associated Glycoprotein Complex Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Regulation Of Intracellular PH Bounding Membrane Of Organelle Regulation Of Cellular PH Regulation Of System Process Metal Ion Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Regulation Of Biological Quality Metal Ion Transport Regulation Of PH Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Cytokine Production Postsynapse Lysosomal Lumen Acidification Anchoring Junction Zinc Ion Transmembrane Transport
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