NONO and SYNPO

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NONO	SYNPO
Name		non-POU domain containing octamer binding	synaptopodin
Structure			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Matrix Nuclear Speck Paraspeckles RNA Polymerase II Transcription Regulator Complex	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Postsynaptic Density Actin Cytoskeleton Z Disc Cell Projection Dendritic Spine Perikaryon Organelle Synapse Anchoring Junction Spine Apparatus Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Identical Protein Binding LncRNA Binding	Actin Binding Protein Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process DNA Repair DNA Recombination Regulation Of DNA-templated Transcription MRNA Processing DNA Damage Response Circadian Rhythm RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Hypoxia Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Angiotensin	Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Spine Apparatus Assembly
GWAS		No GWAS studies recorded	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401 )
Interacting Genes		124 interacting genes: APBB1 AR BHLHE41 C11orf68 CA2 CDK1 CEBPA DANCR DDX6 DELEC1 ERCC6 ERG ESR1 EWSR1 FXR2 H3-4 IL7R IRAK3 LINC00624 LMO4 MAD1L1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN OGT ORC5 OTUD5 PDE4B PIN1 PLEKHF2 POLR1H POLR2A PPP1CA PPP1CB PPP1CC PRKAA2 PRPF40A PSPC1 PTBP1 RNF8 SAMHD1 SFPQ SMARCB1 SMARCC1 SMARCD1 SPI1 SUMO2 SYNPO TAFAZZIN TCERG1 UBE2I USP11 WBP4	9 interacting genes: CDC5L MAGI1 NCK1 NCK2 NONO NUFIP2 SGF29 YWHAG YWHAZ
Entrez ID		4841	11346
HPRD ID		02098	12179
Ensembl ID		ENSG00000147140	ENSG00000171992
Uniprot IDs		A0A0S2Z4Z9 Q15233	Q8N3V7
PDB IDs		3SDE 5IFM 6WMZ 7LRQ 7LRU 7PU5	Not available
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Negative Regulation Of Developmental Process Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration	Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Protein Sequestering Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Domain Specific Binding Response To Stress Positive Regulation Of Translation In Response To Stress Receptor Tyrosine Kinase Binding Signal Complex Assembly Cellular Response To Stress Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translational Initiation Positive Regulation Of Cell-cell Adhesion Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Intracellular Signal Transduction Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Signal Transduction Positive Regulation Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling RNA Binding Signaling Receptor Complex Adaptor Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Intrinsic Apoptotic Signaling Pathway Lamellipodium Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Vesicle Membrane Positive Regulation Of Response To Endoplasmic Reticulum Stress Lamellipodium Organization Response To Endoplasmic Reticulum Stress Positive Regulation Of Translational Initiation Positive Regulation Of Actin Filament Polymerization Molecular Condensate Scaffold Activity Cellular Response To Glucose Starvation Negative Regulation Of Response To Endoplasmic Reticulum Stress Ephrin Receptor Signaling Pathway Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process