URI1 and TRIM28

Number of citations of the paper that reports this interaction (PubMedID 37805657)
54

Data Source:
BioGRID (affinity chromatography technology, pull down)

		URI1	TRIM28
Description		URI1 prefoldin like chaperone	tripartite motif containing 28
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite Protein-containing Complex Cell Projection Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-like Protein Ligase Activity Chromo Shadow Domain Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Stabilization Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Embryo Implantation Positive Regulation Of Macromolecule Metabolic Process Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus Epigenetic Programming Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Genomic Imprinting
Pathways			Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Body mass index ( 26426971) Cerebrospinal P-tau181p levels ( 28247064) Diastolic blood pressure ( 27841878) Serum urate levels in chronic kidney disease ( 30181573)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		11 interacting genes: AKT1 APP ATF7 DMAP1 GTF2F2 ITCH NEDD4 POLR2E RPS6KB1 STAP1 TRIM28	90 interacting genes: CBX1 CBX3 CBX5 CCAR2 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 EAF1 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LIN28A LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGEC2 MAGED1 MAPKAPK2 MCM3 MCM5 MORC2 MYB NR3C1 NR4A1 NR4A3 NSMCE3 OGT PFDN5 PHF13 PPP2CA PRKAA1 PTEN RB1 RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SMURF2 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2L6 UBE2N UBE2U UBE3D URI1 VHL VIM YWHAQ ZBTB33 ZNF10 ZNF133 ZNF197 ZNF274 ZNF354A ZNF354C ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93
Entrez ID		8725	10155
HPRD ID		11943	03445
Ensembl ID		ENSG00000105176	ENSG00000130726
Uniprot IDs		O94763	Q13263
PDB IDs			1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1 7Z36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Intracellular Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Macromolecule Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Protein Metabolic Process Defense Response Post-translational Protein Modification Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Localization Nucleoplasm Positive Regulation Of Defense Response Cell Cortex Negative Regulation Of Macromolecule Biosynthetic Process Proteasomal Protein Catabolic Process Negative Regulation Of Mononuclear Cell Migration	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Ubiquitin Conjugating Enzyme Activity Nucleoplasm Cellular Response To Stress DNA Damage Response Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein-containing Complex PML Body DNA Binding Positive Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Binding Protein Catabolic Process Chromatin Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein K48-linked Ubiquitination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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