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URI1 and RPS6KB1
Number of citations of the paper that reports this interaction (PMID
21397856
)
8
Data Source:
BioGRID
(enzymatic study)
URI1
RPS6KB1
Gene Name
URI1, prefoldin-like chaperone
ribosomal protein S6 kinase, 70kDa, polypeptide 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
DNA-directed RNA Polymerase II, Core Complex
Cytoplasm
Mitochondrion
Dendrite
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cell Surface
Cell Junction
Neuron Projection
Synapse
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Transcription Corepressor Activity
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Phosphatase Inhibitor Activity
Protein Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Peptide Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Growth
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Response To Virus
Negative Regulation Of Phosphatase Activity
Cellular Response To Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Skeletal Muscle Contraction
Protein Phosphorylation
Apoptotic Process
Signal Transduction
Germ Cell Development
Aging
Response To Nutrient
Long-term Memory
Insulin Receptor Signaling Pathway
Response To Heat
Response To Wounding
Response To Mechanical Stimulus
Response To Toxic Substance
Response To Glucose
Skeletal Muscle Atrophy
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
TOR Signaling
Response To Lipopolysaccharide
Response To Testosterone
Response To Glucagon
Response To Tumor Necrosis Factor
Response To Drug
Negative Regulation Of Apoptotic Process
Response To Leucine
Protein Kinase B Signaling
Response To Ethanol
Positive Regulation Of Translation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Translational Initiation
Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Skeletal Muscle Tissue Growth
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Glucocorticoid
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Insulin receptor signalling cascade
IRS-mediated signalling
mTOR signalling
S6K1 signalling
S6K1-mediated signalling
IRS-related events
mTOR signalling
mTORC1-mediated signalling
IGF1R signaling cascade
S6K1-mediated signalling
mTORC1-mediated signalling
IRS-related events triggered by IGF1R
IRS-mediated signalling
S6K1 signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PKB-mediated events
PKB-mediated events
PI3K Cascade
PI3K Cascade
Signaling by Insulin receptor
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
21833088
)
Obesity-related traits (
23251661
)
Protein-Protein Interactions
9 interactors:
APP
ATF7
DMAP1
GTF2F2
ITCH
NEDD4
POLR2E
RPS6KB1
STAP1
54 interactors:
ACTA1
AKT1
APP
BTK
CDC42
CDK1
CLEC3B
COASY
CSNK2A1
CSNK2B
DPPA4
EEF2K
EIF4B
EIF4EBP1
EP300
GDI2P1
HTT
IRS1
KAT2B
KIR3DL1
LYN
MAPK1
MAPK3
MAPK8
MAPK9
MAPT
MLST8
MTOR
MXD1
NCBP1
NEDD4
NEK6
NR1I2
PDK1
PDPK1
PIK3CA
PIN1
POLDIP3
PPP1R9A
PPP1R9B
PPP2CA
RAC1
RBX1
RHEB
RICTOR
RPS6
RPTOR
SRC
STK11
SYK
TERT
TRAF4
URI1
XPO1
Entrez ID
8725
6198
HPRD ID
11943
10202
Ensembl ID
ENSG00000105176
ENSG00000108443
Uniprot IDs
O94763
B2R779
B4DLT4
B4DTG1
F6UYM1
P23443
Q7Z721
PDB IDs
3A60
3A61
3A62
4L3J
4L3L
4L42
4L43
4L44
4L45
4L46
Enriched GO Terms of Interacting Partners
?
Viral Process
Regulation Of Gene Expression
Intracellular Receptor Signaling Pathway
Regulation Of Growth
7-methylguanosine MRNA Capping
Protein K63-linked Ubiquitination
7-methylguanosine RNA Capping
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Viral Transcription
Neuromuscular Junction Development
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Transmission Of Virus
Development Involved In Symbiotic Interaction
Regulation Of Nitrogen Compound Metabolic Process
MRNA Processing
DNA-templated Transcription, Elongation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Response To Stress
Regulation Of Synapse Structure Or Activity
Regulation Of Metabolic Process
Interaction With Host
Regulation Of Type I Interferon Production
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Nucleocytoplasmic Transport
Synaptic Growth At Neuromuscular Junction
Positive Regulation Of Skeletal Muscle Tissue Growth
Locomotion
Positive Regulation Of Mitotic Cell Cycle
MRNA Metabolic Process
Immune Response
Negative Regulation Of Gene Expression
RNA Processing
Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Collateral Sprouting In Absence Of Injury
Notch Signaling Pathway
Regulation Of Viral Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Protein Polyubiquitination
Skeletal Muscle Atrophy
Cellular Response To Organic Substance
Response To Organic Substance
Regulation Of Protein Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Insulin Stimulus
Response To Insulin
Insulin Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Peptide Hormone Stimulus
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Peptide
Cellular Response To Organonitrogen Compound
Fc Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Hormone
Fc-epsilon Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Phosphorylation
Response To Peptide Hormone
Positive Regulation Of Protein Metabolic Process
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Response To Peptide
Regulation Of Signal Transduction
Regulation Of Phosphorylation
Cellular Response To Stimulus
Positive Regulation Of Protein Phosphorylation
Response To Organonitrogen Compound
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Signal Transduction
Regulation Of Signaling
Innate Immune Response
Intracellular Signal Transduction
Signaling
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Signal Transduction
Cell Communication
Immune Response
Positive Regulation Of Protein Modification Process
Regulation Of Kinase Activity
Regulation Of Metabolic Process
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Metabolic Process
T Cell Costimulation
Response To Growth Factor
Neurotrophin TRK Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud
?
70kda
ablation
amp
ampk
aortas
apoe
apolipoprotein
arg2
arginase
atherogenesis
atherosclerosis
atherosclerotic
autophagy
crosstalk
h160f
impairs
interested
mtorc1
mtorc2
nonsenescent
polypeptide
prkaa
replicative
rictor
s6k1
senescent
ureahydrolase
wk
Tagcloud (Difference)
?
70kda
ablation
amp
ampk
aortas
apoe
apolipoprotein
arg2
arginase
atherogenesis
atherosclerosis
atherosclerotic
autophagy
crosstalk
h160f
impairs
interested
mtorc1
mtorc2
nonsenescent
polypeptide
prkaa
replicative
rictor
s6k1
senescent
ureahydrolase
wk
Tagcloud (Intersection)
?