URI1

Description		URI1 prefoldin like chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Dendrite Protein-containing Complex Cell Projection Protein Folding Chaperone Complex RPAP3/R2TP/prefoldin-like Complex
	Molecular Function	RNA Polymerase II Complex Binding Chromatin Binding Transcription Corepressor Activity Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Inhibitor Activity Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Regulation Of Transcription By RNA Polymerase II Response To Virus Negative Regulation Of Phosphatase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Stabilization Cellular Response To Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Cerebrospinal P-tau181p levels ( 28247064) Diastolic blood pressure ( 27841878) Serum urate levels in chronic kidney disease ( 30181573)
Novel Interacting Genes		1 novel interacting genes: MEGF8
Interacting Genes		11 interacting genes: AKT1 APP ATF7 DMAP1 GTF2F2 ITCH NEDD4 POLR2E RPS6KB1 STAP1 TRIM28
Entrez ID		8725
HPRD ID		11943
Ensembl ID		ENSG00000105176
Uniprot IDs		O94763
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Intracellular Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Enzyme Binding Macromolecule Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Protein Metabolic Process Defense Response Post-translational Protein Modification Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Protein Localization Nucleoplasm Positive Regulation Of Defense Response Cell Cortex Negative Regulation Of Macromolecule Biosynthetic Process Proteasomal Protein Catabolic Process Negative Regulation Of Mononuclear Cell Migration
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