HIST2H4A and BRD4

Number of citations of the paper that reports this interaction (PMID 18500820)
15

Data Source:
BioGRID (pull down)

		HIST2H4A	BRD4
Gene Name		histone cluster 2, H4a	bromodomain containing 4
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Positive Transcription Elongation Factor Complex B
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity	P53 Binding DNA Binding Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation Chromatin Remodeling Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Histone H4-K12 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of DNA Damage Checkpoint
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ATAD2 BRD4 BRDT DNMT3L EP300 HAT1 HIST1H3A HIST2H2AC KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UBC UCHL5 UHRF1 YWHAQ	18 interactors: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 HIST2H3C HIST2H4A HIST4H4 JMJD6 MESDC2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 TCERG1
Entrez ID		8370	23476
HPRD ID		11821	10574
Ensembl ID		ENSG00000183941	ENSG00000141867
Uniprot IDs		B2R4R0 P62805	O60885
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA	2I8N 2LSP 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4KV1 4KV4 4LR6 4LRG 4MEN 4MEO 4MEP 4MEQ
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Transcription, DNA-templated Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation RNA Biosynthetic Process Protein Acetylation Nucleosome Organization Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process DNA Metabolic Process DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Cellular Metabolic Process Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Chromatin Assembly Histone H4 Acetylation Peptidyl-lysine Modification DNA Methylation On Cytosine Chromatin Assembly Or Disassembly Positive Regulation Of Metabolic Process	Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleotide-excision Repair DNA-dependent DNA Replication Mitotic Cell Cycle Homeostatic Process DNA Methylation On Cytosine Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Chromatin Silencing Histone Demethylation Protein Demethylation Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Organelle Organization DNA Methylation Demethylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly DNA Modification Cellular Metabolic Process DNA Repair Cell Cycle Process Gene Silencing Cellular Homeostasis Regulation Of Megakaryocyte Differentiation Gene Expression Cell Division CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process
Tagcloud ?			3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Difference) ?			3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Intersection) ?