ARHGAP24 and FLNA

Number of citations of the paper that reports this interaction (PMID 16862148)
88

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ARHGAP24	FLNA
Gene Name		Rho GTPase activating protein 24	filamin A, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Focal Adhesion Cell Projection	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite
	Molecular Function	Protein Binding Rac GTPase Activator Activity	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding
	Biological Process	Angiogenesis Small GTPase Mediated Signal Transduction Cell Differentiation Activation Of Rac GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Ruffle Assembly	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062063) Obesity-related traits ( 23251661) PR interval ( 20062060 23139255)
Protein-Protein Interactions		3 interactors: APP FLNA ROCK1	82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG
Entrez ID		83478	2316
HPRD ID		09804	02060
Ensembl ID		ENSG00000138639	ENSG00000196924
Uniprot IDs		Q8N264	P21333 Q60FE5 Q6NXF2
PDB IDs			2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Cell Projection Organization Cell Adhesion Platelet Activation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cell Projection Assembly Cell Development Cellular Component Assembly Collateral Sprouting Axon Midline Choice Point Recognition Membrane To Membrane Docking Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Apical Constriction Axon Choice Point Recognition Axon Guidance Blood Coagulation Hemostasis Posttranscriptional Regulation Of Gene Expression Anatomical Structure Morphogenesis Neuron Remodeling Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Bleb Assembly Secretion By Cell MRNA Transcription From RNA Polymerase II Promoter Single Organismal Cell-cell Adhesion Axonogenesis Myoblast Migration Leukocyte Tethering Or Rolling Axon Development MRNA Transcription Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Secretion Neuron Projection Morphogenesis Actin Filament-based Process Cellular Copper Ion Homeostasis Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface Cell Activation Mitotic Spindle Assembly Early Endosome To Late Endosome Transport	Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process
Tagcloud ?		acted antagonizing catalytic contributes drives encodes gtpase independently invasion luminal mesenchymal metastasis microrna module oncogenic opposed overexpressed poorly promoted promotes rac1 ras rasal2 relapse subset tnbc triple tumorigenesis	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		acted antagonizing catalytic contributes drives encodes gtpase independently invasion luminal mesenchymal metastasis microrna module oncogenic opposed overexpressed poorly promoted promotes rac1 ras rasal2 relapse subset tnbc triple tumorigenesis	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?