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H2BC13 and VHL
Number of citations of the paper that reports this interaction (PubMedID
22234250
)
29
Data Source:
BioGRID
(pull down)
H2BC13
VHL
Description
H2B clustered histone 13
von Hippel-Lindau tumor suppressor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleosome
Nucleus
Nucleoplasm
Chromosome
Cytosol
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Membrane
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Protein Heterodimerization Activity
Transcription Elongation Factor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Enzyme Binding
Molecular Adaptor Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
Nucleosome Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Response To Hypoxia
Regulation Of DNA-templated Transcription
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Signal Transduction
Regulation Of Gene Expression
Negative Regulation Of Autophagy
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Cellular Response To Hypoxia
Regulation Of Cellular Response To Hypoxia
Negative Regulation Of TORC1 Signaling
Amyloid Fibril Formation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
Renal cell carcinoma
GWAS
Bullous pemphigoid (
34011352
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
5 interacting genes:
AP2M1
CDC42
H2AB2
H2AB3
VHL
172 interacting genes:
ACTB
AHI1
AKT1
ANKEF1
ANKRD11
APP
ARHGEF7
AURKA
BEX2
BEX4
BRCA1
BRD4
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CCT5
CCT7
CD44
CDC34
CDK1
CDK5RAP3
CDKN2A
CERKL
CHEK2
CLU
COL4A2
COMMD1
CPNE5
CSNK2A1
CUL2
CUL5
DGKI
DIDO1
DNAJA3
DSTN
DVL2
E2F1
EEF1A1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
ERI1
ETFA
FBXO28
FBXO34
FKBP8
FLNA
FLOT1
FN1
GHET1
GPANK1
GPS1
GTF3C2
GUK1
H1-2
H2BC13
H4C16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IFT88
IKBKB
ITPKC
JADE1
KIF2C
KIF3A
KLF4
KLHL10
LANCL1
MAP1B
MAP1LC3B
MAP1S
MDFI
MRPS9
MSL2
MT-CO2
NCL
NISCH
NR4A1
NR4A2
NR4A3
NSUN5
NSUN7
OTUD6B
PAX2
PDCD5
PFKP
PHB2
PIAS4
PIWIL4
PKP2
PLD1
PLD2
POLR2G
PPP1R13L
PPP5C
PRDX1
PRKCI
PRKG1
PRMT1
PRMT8
PSMC1
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RERE
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SAP30
SARNP
SAT2
SELENOP
SETDB1
SKP2
SLC2A1
SLC3A2
SMC5
SNRNP200
SON
SP1
SPARC
SPATA22
SPZ1
STAMBP
SUV39H2
TBK1
TDRD7
TEX35
TPT1
TRIM28
TTC3
UBE2D1
UBE2D2
UBE2D3
UBE2I
USP20
USP33
USP9X
UXT
VAPB
VBP1
VRK1
WSB1
YY1AP1
ZBTB17
ZNF197
ZNF200
ZNF512B
ZNF668
ZNF827
Entrez ID
8340
7428
HPRD ID
11898
01905
Ensembl ID
ENSG00000185130
ENSG00000134086
Uniprot IDs
Q99880
A0A024R2F2
A0A0S2Z4K1
A0A8Q3WL21
P40337
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
7CJB
7JTO
7JTP
7KHH
7PI4
7Q2J
7S4E
7Z6L
7Z76
7Z77
7ZNT
8BB2
8BB3
8BB4
8BB5
8BDI
8BDJ
8BDL
8BDM
8BDN
8BDO
8BDS
8BDT
8BDX
8BEB
8C13
8CQE
8CQK
8CQL
8EI3
8EWV
8FY0
8FY1
8FY2
8G1P
8G1Q
8P0F
8PC2
8QJR
8QJS
8QU8
8QVU
8QW6
8QW7
8R5H
8RWZ
8RX0
8VL9
8VLB
8WDK
8YMB
8ZV8
8ZVJ
9BJU
9BOL
9EQJ
9EQM
9IPW
Enriched GO Terms of Interacting Partners
?
Amyloid Fibril Formation
Endothelin Receptor Signaling Pathway Involved In Heart Process
GBD Domain Binding
Storage Vacuole
Cellular Component Assembly
Supramolecular Fiber Organization
Protein-containing Complex Organization
Protein-containing Complex Assembly
Positive Regulation Of Interleukin-6-mediated Signaling Pathway
Ripoptosome Assembly
Death Domain Binding
Ripoptosome Assembly Involved In Necroptotic Process
Nucleosome
Heterochromatin Formation
Nucleosome Assembly
Euchromatin
Nucleosome Organization
Structural Constituent Of Chromatin
Positive Regulation Of Endocytosis
Apolipoprotein A-I Receptor Binding
Neuropilin Signaling Pathway
Signal Sequence Binding
Negative Regulation Of Gene Expression, Epigenetic
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Positive Regulation Of MiRNA Processing
Peptidyl-serine Autophosphorylation
Protein-DNA Complex Assembly
Positive Regulation Of Pinocytosis
G Protein-coupled Receptor Signaling Pathway Involved In Heart Process
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Establishment Of Golgi Localization
Postsynapse
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Positive Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Synaptic Vesicle Recycling
Postsynaptic Neurotransmitter Receptor Internalization
Transcription Elongation Factor Activity
Ripoptosome
Death-inducing Signaling Complex
Positive Regulation Of Necroptotic Process
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
JUN Kinase Kinase Kinase Activity
Necroptotic Signaling Pathway
Leading Edge Membrane
Thioesterase Binding
Neuron Fate Determination
Golgi Transport Complex
Positive Regulation Of Programmed Necrotic Cell Death
Epigenetic Regulation Of Gene Expression
Endothelin Receptor Signaling Pathway
Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Cytoplasm
Post-translational Protein Modification
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Cellular Response To Stress
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Cytosol
Protein Modification Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Protein Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Protein-containing Complex
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Stability
Chromatin Remodeling
Positive Regulation Of Biosynthetic Process
NF-kappaB Binding
Response To Stress
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
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