H2BC13 and H2AB3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		H2BC13	H2AB3
Name		H2B clustered histone 13	H2A.B variant histone 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol Extracellular Exosome	Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Nucleosome Assembly	Nucleosome Assembly MRNA Processing Heterochromatin Formation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: RIPK1	None recorded
Interacting Genes		5 interacting genes: AP2M1 CDC42 H2AB2 H2AB3 VHL	3 interacting genes: H2BC13 H2BC15 MESD
Entrez ID		8340	83740
HPRD ID		11898	06581
Ensembl ID		ENSG00000185130	ENSG00000277745
Uniprot IDs		Q99880	P0C5Z0
PDB IDs		Not available	6A7U 6M4G 6M4H
GO Terms Enriched among Interactors		Amyloid Fibril Formation Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Cellular Component Assembly Supramolecular Fiber Organization Protein-containing Complex Organization Protein-containing Complex Assembly Positive Regulation Of Interleukin-6-mediated Signaling Pathway Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process Nucleosome Heterochromatin Formation Nucleosome Assembly Euchromatin Nucleosome Organization Structural Constituent Of Chromatin Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Signal Sequence Binding Negative Regulation Of Gene Expression, Epigenetic Extrinsic Component Of Presynaptic Endocytic Zone Membrane Positive Regulation Of MiRNA Processing Peptidyl-serine Autophosphorylation Protein-DNA Complex Assembly Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Postsynapse Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Transcription Elongation Factor Activity Ripoptosome Death-inducing Signaling Complex Positive Regulation Of Necroptotic Process Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis JUN Kinase Kinase Kinase Activity Necroptotic Signaling Pathway Leading Edge Membrane Thioesterase Binding Neuron Fate Determination Golgi Transport Complex Positive Regulation Of Programmed Necrotic Cell Death Epigenetic Regulation Of Gene Expression Endothelin Receptor Signaling Pathway	Nucleosome Nucleosome Assembly Nucleosome Organization Structural Constituent Of Chromatin Protein-DNA Complex Assembly Protein Heterodimerization Activity Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Chromatin Remodeling Chromosome Low-density Lipoprotein Particle Receptor Binding Protein Localization To Cell Surface Chromatin Organization Mesoderm Development Protein Folding Chaperone