NLRC4 and BCL10

Number of citations of the paper that reports this interaction (PubMedID 11472070)
0

Data Source:
HPRD (in vitro, in vivo)

		NLRC4	BCL10
Description		NLR family CARD domain containing 4	BCL10 immune signaling adaptor
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptotic Inflammatory Response	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		6 interacting genes: BCL10 CASP1 FOXP1 NLRP4 NOD2 PYCARD	45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		58484	8915
HPRD ID		06014	04625
Ensembl ID		ENSG00000091106	ENSG00000142867
Uniprot IDs		Q9NPP4	A0A087WWW9 A2TDT2 O95999
PDB IDs		6K8J 6MKS 6N1I 8FVU 8FW2 8FW9	2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity CARD Domain Binding Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of DNA-binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Regulation Of Interleukin-1 Production Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway AIM2 Inflammasome Complex Cellular Response To Lipopolysaccharide Positive Regulation Of Cytokine Production Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Leukocyte Apoptotic Process Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Apoptotic Process NLRP1 Inflammasome Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Production Protein-containing Complex Positive Regulation Of Innate Immune Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Immune Response-activating Signaling Pathway Positive Regulation Of Interleukin-6 Production Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical Inflammasome Complex Negative Regulation Of B Cell Apoptotic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune System Process	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process
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