NLRC4 and NLRP4

Number of citations of the paper that reports this interaction (PMID 15107016)
42

Data Source:
HPRD (in vitro)

		NLRC4	NLRP4
Gene Name		NLR family, CARD domain containing 4	NLR family, pyrin domain containing 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Spindle Microtubule IPAF Inflammasome Complex	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	ATP Binding
	Biological Process	Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Regulation Of Signal Transduction Detection Of Bacterium Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Inflammatory Response Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response
Pathways		Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways The IPAF inflammasome Innate Immune System	ZBP1(DAI) mediated induction of type I IFNs Regulation of innate immune responses to cytosolic DNA IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BCL10 CASP1 NLRP4 NOD2 PYCARD	2 interactors: CHUK NLRC4
Entrez ID		58484	147945
HPRD ID		06014	09619
Ensembl ID		ENSG00000091106	ENSG00000160505
Uniprot IDs		Q9NPP4	B2RCA1 Q96MN2
PDB IDs			4EWI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytokine Production Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Interleukin-1 Beta Production Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Secretion Immune Response Defense Response Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Activation Of Innate Immune Response Positive Regulation Of Peptidase Activity Interleukin-1 Beta Production Response To Other Organism Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Biotic Stimulus Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of T Cell Activation Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Positive Regulation Of Interleukin-10 Production Regulation Of Inflammatory Response Positive Regulation Of Interleukin-8 Production Regulation Of T Cell Activation Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1 Beta Secretion Inflammatory Response Response To Bacterium Pyroptosis Interleukin-1 Secretion Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Secretion Positive Regulation Of Immune Response Response To Other Organism Response To Biotic Stimulus Interleukin-1 Beta Production Innate Immune Response I-kappaB Phosphorylation Regulation Of Immune Response Positive Regulation Of Immune System Process Mitotic Spindle Assembly Detection Of Bacterium Mammary Gland Epithelial Cell Proliferation Response To Hydroperoxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Detection Of Biotic Stimulus Skeletal Muscle Contraction Cytokine Secretion Immune Response Regulation Of Immune System Process Defense Response Mitotic Spindle Organization Musculoskeletal Movement Mammary Gland Alveolus Development Mammary Gland Lobule Development Osteoclast Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Lactation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Rho Protein Signal Transduction Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Morphogenesis Of An Epithelial Sheet TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide nlrp3 oligomeric oligomerization online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally	aureus chordates confirming cystine deleterious drosophila equivalent evolutionarily exoproteins immunity killing knot neutrophil ngfbeta nlrp3 phagocytosis proinflammatory released shared spaetzle staphylococcus structurally superoxide toll trka tropomyosin unexpected vertebrate zebrafish
Tagcloud (Difference) ?		advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide oligomeric oligomerization online polymerization publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally	aureus chordates confirming cystine deleterious drosophila equivalent evolutionarily exoproteins immunity killing knot neutrophil ngfbeta phagocytosis released shared spaetzle staphylococcus structurally superoxide toll trka tropomyosin unexpected vertebrate zebrafish
Tagcloud (Intersection) ?		nlrp3 proinflammatory