NLRC4 and NLRP4

Number of citations of the paper that reports this interaction (PubMedID 15107016)
28

Data Source:
HPRD (in vitro)

		NLRC4	NLRP4
Description		NLR family CARD domain containing 4	NLR family pyrin domain containing 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding	Nucleotide Binding ATP Binding Molecular Adaptor Activity
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptotic Inflammatory Response	Inflammatory Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Innate Immune Response Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Antiviral Innate Immune Response Protein K33-linked Deubiquitination
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome	IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)	Plasma anti-thyroglobulin levels ( 29678681)
Interacting Genes		6 interacting genes: BCL10 CASP1 FOXP1 NLRP4 NOD2 PYCARD	2 interacting genes: CHUK NLRC4
Entrez ID		58484	147945
HPRD ID		06014	09619
Ensembl ID		ENSG00000091106	ENSG00000160505
Uniprot IDs		Q9NPP4	B2RCA1 Q96MN2
PDB IDs		6K8J 6MKS 6N1I 8FVU 8FW2 8FW9	4EWI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity CARD Domain Binding Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of DNA-binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Regulation Of Interleukin-1 Production Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway AIM2 Inflammasome Complex Cellular Response To Lipopolysaccharide Positive Regulation Of Cytokine Production Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Leukocyte Apoptotic Process Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Apoptotic Process NLRP1 Inflammasome Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Production Protein-containing Complex Positive Regulation Of Innate Immune Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Immune Response-activating Signaling Pathway Positive Regulation Of Interleukin-6 Production Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical Inflammasome Complex Negative Regulation Of B Cell Apoptotic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune System Process	Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Acetate Positive Regulation Of DNA-binding Transcription Factor Activity Activation Of Innate Immune Response Response To Cholecystokinin Positive Regulation Of Innate Immune Response IkappaB Kinase Activity IPAF Inflammasome Complex Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Cytokine Production IkappaB Kinase Complex Inflammatory Response CD40 Receptor Complex Transferrin Receptor Binding Detection Of Bacterium Positive Regulation Of Immune Response Innate Immune Response Caspase Binding Protein Homodimerization Activity Canonical Inflammasome Complex Defense Response To Symbiont Defense Response To Other Organism Endopeptidase Activator Activity Regulation Of Cytokine Production Regulation Of Defense Response Response To Hydroperoxide Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Regulation Of Immune Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Detection Of Biotic Stimulus Non-canonical NF-kappaB Signal Transduction Skeletal Muscle Contraction Response To Other Organism Immune Response Positive Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Pyroptotic Inflammatory Response Icosanoid Biosynthetic Process Cell Surface Toll-like Receptor Signaling Pathway Response To External Biotic Stimulus
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