NLRC4

Gene Name		NLR family, CARD domain containing 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Spindle Microtubule IPAF Inflammasome Complex
	Molecular Function	Magnesium Ion Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Regulation Of Signal Transduction Detection Of Bacterium Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways The IPAF inflammasome Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: BCL10 CASP1 NLRP4 NOD2 PYCARD
Entrez ID		58484
HPRD ID		06014
Ensembl ID		ENSG00000091106
Uniprot IDs		Q9NPP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytokine Production Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Interleukin-1 Beta Production Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Secretion Immune Response Defense Response Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Activation Of Innate Immune Response Positive Regulation Of Peptidase Activity Interleukin-1 Beta Production Response To Other Organism Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Biotic Stimulus Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of T Cell Activation Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Positive Regulation Of Interleukin-10 Production Regulation Of Inflammatory Response Positive Regulation Of Interleukin-8 Production Regulation Of T Cell Activation Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion
Tagcloud ?		advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide nlrp3 oligomeric oligomerization online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally