NLRC4

Description		NLR family CARD domain containing 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Canonical Inflammasome Complex IPAF Inflammasome Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Icosanoid Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptotic Inflammatory Response
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)
Novel Interacting Genes		1 novel interacting genes: ALK
Interacting Genes		6 interacting genes: BCL10 CASP1 FOXP1 NLRP4 NOD2 PYCARD
Entrez ID		58484
HPRD ID		06014
Ensembl ID		ENSG00000091106
Uniprot IDs		Q9NPP4
PDB IDs		6K8J 6MKS 6N1I 8FVU 8FW2 8FW9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity CARD Domain Binding Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of DNA-binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Regulation Of Interleukin-1 Production Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Immune Response Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response-activating Signaling Pathway AIM2 Inflammasome Complex Cellular Response To Lipopolysaccharide Positive Regulation Of Cytokine Production Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Leukocyte Apoptotic Process Response To External Biotic Stimulus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immune Response Regulation Of Apoptotic Process NLRP1 Inflammasome Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Production Protein-containing Complex Positive Regulation Of Innate Immune Response Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Lipid Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Immune Response-activating Signaling Pathway Positive Regulation Of Interleukin-6 Production Response To Stress Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Canonical Inflammasome Complex Negative Regulation Of B Cell Apoptotic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Immune System Process
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