NLRC4 and NOD2

Number of citations of the paper that reports this interaction (PMID 15107016)
42

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		NLRC4	NOD2
Gene Name		NLR family, CARD domain containing 4	nucleotide-binding oligomerization domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Cytosol Spindle Microtubule IPAF Inflammasome Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane COP9 Signalosome Cell Surface Vesicle Protein Complex
	Molecular Function	Magnesium Ion Binding Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Muramyl Dipeptide Binding Peptidoglycan Binding CARD Domain Binding
	Biological Process	Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Regulation Of Signal Transduction Detection Of Bacterium Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Innate Immune Response In Mucosa Cytokine Production Involved In Immune Response Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Type 2 Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria JNK Cascade Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Detection Of Muramyl Dipeptide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Activation Of MAPK Activity Involved In Innate Immune Response Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Growth Of Symbiont In Host Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Positive Regulation Of Oxidoreductase Activity Stress-activated MAPK Cascade Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Macrophage Inflammatory Protein-1 Alpha Production Regulation Of Neutrophil Chemotaxis Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways		Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways The IPAF inflammasome Innate Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464) Leprosy ( 20018961)
Protein-Protein Interactions		5 interactors: BCL10 CASP1 NLRP4 NOD2 PYCARD	5 interactors: ERBB2IP MAP3K7 NLRC4 RIPK2 XIAP
Entrez ID		58484	64127
HPRD ID		06014	05810
Ensembl ID		ENSG00000091106	ENSG00000167207
Uniprot IDs		Q9NPP4	Q9HC29
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytokine Production Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Interleukin-1 Beta Production Response To Molecule Of Bacterial Origin Positive Regulation Of Cytokine Secretion Immune Response Defense Response Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cytokine Secretion Activation Of Innate Immune Response Positive Regulation Of Peptidase Activity Interleukin-1 Beta Production Response To Other Organism Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Response To Biotic Stimulus Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of T Cell Activation Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Positive Regulation Of Interleukin-10 Production Regulation Of Inflammatory Response Positive Regulation Of Interleukin-8 Production Regulation Of T Cell Activation Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Response To Lipopolysaccharide Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Innate Immune Response Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Immune Response Negative Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Programmed Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Immune System Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity JNK Cascade Positive Regulation Of Immune Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide nlrp3 oligomeric oligomerization online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally	aspergillus conidia crosstalk dipeptide fumigates fumigatus hcecs immortalized immunity initiating innate interrelationship keratitis leucine mdp muramyl nfkappab nlrs oligomerization pamps prr prrs recognize rip2 surprise tlr2 tlrs toll zymosan
Tagcloud (Difference) ?		advance aim2 antagonizes asc card doi excessive icb immunology inflammasome lipopolysaccharide nlrp3 oligomeric online polymerization proinflammatory publication reconstituted redistribution speck stat6 subcellular suppress suppresses th2 thp tlr transcriptionally	aspergillus conidia crosstalk dipeptide fumigates fumigatus hcecs immortalized immunity initiating innate interrelationship keratitis leucine mdp muramyl nfkappab nlrs pamps prr prrs recognize rip2 surprise tlr2 tlrs toll zymosan
Tagcloud (Intersection) ?		oligomerization