CAPZA1 and HSPA8

Number of citations of the paper that reports this interaction (PMID 20884878)
7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CAPZA1	HSPA8
Gene Name		capping protein (actin filament) muscle Z-line, alpha 1	heat shock 70kDa protein 8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Vesicular Exosome WASH Complex	Ubiquitin Ligase Complex Prp19 Complex Extracellular Space Intracellular Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytosol Plasma Membrane Focal Adhesion Membrane Ribonucleoprotein Complex Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Actin Binding Protein Binding	G-protein Coupled Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding MHC Class II Protein Complex Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Protein Complex Assembly Movement Of Cell Or Subcellular Component Blood Coagulation Innate Immune Response Barbed-end Actin Filament Capping	MRNA Splicing, Via Spliceosome Transcription, DNA-templated Protein Folding Post-Golgi Vesicle-mediated Transport Response To Unfolded Protein Synaptic Transmission Neurotransmitter Secretion Axon Guidance RNA Splicing Gene Expression Viral Process Cellular Response To Heat Protein Refolding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Cell Cycle Membrane Organization Clathrin Coat Disassembly Regulation Of Cellular Response To Heat Negative Regulation Of Fibril Organization
Pathways		Factors involved in megakaryocyte development and platelet production Advanced glycosylation endproduct receptor signaling Innate Immune System	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Regulation of mRNA stability by proteins that bind AU-rich elements Axon guidance Golgi Associated Vesicle Biogenesis Attenuation phase mRNA Splicing - Major Pathway L1CAM interactions Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA GABA synthesis, release, reuptake and degradation Clathrin derived vesicle budding Lysosome Vesicle Biogenesis HSF1-dependent transactivation Neurotransmitter Release Cycle CHL1 interactions trans-Golgi Network Vesicle Budding Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Blood pressure ( 21572416)
Protein-Protein Interactions		7 interactors: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5	83 interactors: ABI1 AIPL1 ALDOB APOB BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCAR2 CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DNAJB1 DNAJC7 DPP3 DYNLL1 EGFR ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTT IL32 JAK2 JUN LALBA MAPK8 MAPT METTL21A NMI NOA1 PHC1 PPID RAF1 RB1 REL RGS2 SGTA SNCA SP1 SRRT ST13 STIP1 STMN1 STUB1 SUMO4 TADA3 TCERG1 TCP1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ
Entrez ID		829	3312
HPRD ID		03347	07205
Ensembl ID		ENSG00000116489	ENSG00000109971
Uniprot IDs		P52907	P11142 Q53HF2
PDB IDs		1MQ1 1MWN	3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4HWI
Enriched GO Terms of Interacting Partners?		Midbrain Development Substantia Nigra Development 'de Novo' Posttranslational Protein Folding Central Nervous System Development 'de Novo' Protein Folding Neural Nucleus Development Cellular Response To Stimulus Nervous System Development Cell Projection Organization Locomotion Negative Regulation Of Fibril Organization Axonogenesis Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Neuron Projection Morphogenesis Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Fibril Organization Cell Morphogenesis Involved In Differentiation Regulation Of Cell Shape Signaling Brain Development Negative Regulation Of Skeletal Muscle Cell Differentiation Cell Communication Head Development Regulation Of Cellular Component Organization Neuron Projection Development Clathrin Coat Disassembly Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Neuron Development System Development Cell Morphogenesis Protein Folding Anatomical Structure Morphogenesis Response To Methylmercury Neuron Differentiation Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Axon Guidance Anatomical Structure Development Regulation Of Skeletal Muscle Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Refolding	Regulation Of Cell Death Protein Folding Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Cell Death Death Protein Refolding Response To Stress Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Organic Substance Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Abiotic Stimulus Protein Metabolic Process Regulation Of Protein Stability Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signaling Defense Response Chaperone Cofactor-dependent Protein Refolding Regulation Of Intracellular Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Signal Transduction Cell Communication Cellular Response To Organic Substance Protein Complex Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Difference) ?		cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	alteration cadherin cd133 cognate ectopically electrophoresis filament glioblastoma glioblastomas gliomas hairpin hsc71 interfere invasion modulating nanog nestin oct overexpress progenitor restored shrna sphere stemness suppresses transfected transfection tumorigenic vi
Tagcloud (Intersection) ?