AGTRAP and AGTR2

Number of citations of the paper that reports this interaction (PubMedID 11733189)
0

Data Source:
BioGRID (pull down)

		AGTRAP	AGTR2
Description		angiotensin II receptor associated protein	angiotensin II receptor type 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Plasma Membrane Membrane
	Molecular Function	Angiotensin Type II Receptor Activity Protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BRAF and RAF1 fusions	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Tasosartan CYT006-AngQb Olodanrigan
Diseases			Non-syndromic X-linked mental retardation
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Basophil percentage of white cells ( 32888494) Systolic blood pressure ( 19430483)	Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)
Interacting Genes		138 interacting genes: ACSF2 AGTR1 AGTR2 ALDH18A1 ANKS6 AP3M1 APOA4 AQP6 ARAF ARFIP2 ARHGAP1 ATP5F1E BCL2L13 BPIFA2 CAPNS1 CCDC70 CD160 CD79A CELA3A CIAO2A COQ8A CPLX1 CPLX4 CRCT1 CYB5R3 CYBC1 DDA1 DDX55 DGCR6 DIABLO DNAJC1 ECPAS ERGIC3 ETFRF1 FAM114A1 FAM209A FARS2 FASTKD3 FATE1 FFAR2 FGA FHIP1B FNDC9 GABARAPL2 GAD1 GAD2 GDNF GPR152 GPX8 GTF2H1 GTF3C1 H4C7 HARS2 HIBADH HMGB1 HSBP1L1 HSCB HSD17B13 HSFX1 HSFX2 HSPA4 IL7R ISCU KCNK5 KIR2DL3 KIR3DL3 LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MGST3 MIEF1 MIEF2 MMD MRM1 MRPL11 MRRF MTERF3 MUTYH MYG1 NDRG4 NDUFAF3 NFU1 NFYB NKG7 PBX3 PCTP PCYT1A PDHX PIMREG PITPNC1 PNPO POLDIP2 PPIF PRPF18 PTPN9 RAB30 RACK1 RBFA RETREG3 RMDN2 S100B SCAND1 SENP2 SH3GLB1 SLC18A1 SLC7A14 SMG9 SNX1 SPG21 SSX3 SSX5 STAG3L1 STAR STARD4 STMN4 STX1A SUCLA2 SYT16 TBRG4 TCEA2 TCEANC2 TFAM THAP4 TMEM139 TMEM14B TMEM31 TMPPE TPD52L3 TTPA TUBA1B TXN2 UBE2I YARS2 ZFYVE21 ZNF391	13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		57085	186
HPRD ID		16379	02071
Ensembl ID		ENSG00000177674	ENSG00000180772
Uniprot IDs		Q6RW13	P50052
PDB IDs			5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
Enriched GO Terms of Interacting Partners?		Mitochondrial Matrix Mitochondrion Protein Binding Lipid Binding Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity
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