AGTRAP and MUTYH

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AGTRAP	MUTYH
Gene Name		angiotensin II receptor-associated protein	mutY homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Angiotensin Type II Receptor Activity Protein Binding	Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway	DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Depurination
Pathways			Depurination Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Base-Excision Repair, AP Site Formation Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS		Systolic blood pressure ( 19430483)
Protein-Protein Interactions		70 interactors: ACSF2 ADCK3 AGTR1 AGTR2 ALDH18A1 AP3M1 ARAF ARFIP2 BPIFA2 C12orf10 CAPNS1 CD160 CPLX1 CRCT1 DDA1 DDX55 DGCR6 FAM114A1 FAM160A2 FAM64A FARS2 FASTKD3 FATE1 GABARAPL2 GAD1 GAD2 GDNF GNB2L1 GTF3C1 HARS2 HIST1H4G HMGB1 HSCB HSPA4 ISCU KIAA0368 LMO2 LNX1 MCEE MIEF1 MIEF2 MRM1 MTERF3 MUTYH NDRG4 NFU1 NFYB NKG7 PBX3 PCTP PDHX PITPNC1 PTPN9 RMDN2 SENP2 SNX1 SPG21 SSX3 SSX5 STAG3L1 SUCLA2 SYT16 TBRG4 TCEANC2 TFAM TPD52L3 TUBA1B TXN2 ZFYVE21 ZNF391	7 interactors: AGTRAP APEX1 LRSAM1 MSH6 PCNA RPA1 RPA4
Entrez ID		57085	4595
HPRD ID		16379	05380
Ensembl ID		ENSG00000177674	ENSG00000132781
Uniprot IDs		Q6RW13	D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 Q9UIF7
PDB IDs			1X51 3N5N
Enriched GO Terms of Interacting Partners?		Succinate Metabolic Process Glutamate Decarboxylation To Succinate Glutamate Metabolic Process Iron-sulfur Cluster Assembly Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Angiotensin-activated Signaling Pathway Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Protein Homooligomerization Positive Regulation Of Mitochondrial Fission Small Molecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Mitochondrial Fission Regulation Of Blood Volume By Renin-angiotensin Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Carboxylic Acid Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Oligomerization Regulation Of Renal Sodium Excretion Regulation Of Branching Involved In Ureteric Bud Morphogenesis Carboxylic Acid Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Organic Acid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Excretion Exploration Behavior Regulation Of Protein Oligomerization Neurotransmitter Metabolic Process Neurotransmitter Secretion Mitochondrion Organization Ornithine Biosynthetic Process Negative Regulation Of Apoptotic Cell Clearance Succinyl-CoA Pathway Posterior Compartment Specification Anterior Compartment Pattern Formation Aldosterone Secretion Nitrogen Fixation Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure L-methylmalonyl-CoA Metabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Protein Targeting To Membrane Metanephros Morphogenesis Cellular Amino Acid Catabolic Process Cardiac Muscle Tissue Growth Biosynthetic Process	Mismatch Repair DNA Recombination Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Replication Base-excision Repair Cellular Response To DNA Damage Stimulus Telomere Maintenance Cell Cycle Process DNA Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle Cellular Response To Stress Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Deoxyribonuclease Activity Ubiquitin-dependent Endocytosis Leading Strand Elongation Organelle Organization DNA Catabolic Process Mitotic Cell Cycle Process Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Cellular Homeostasis Meiotic Mismatch Repair Meiotic Nuclear Division DNA Recombinase Assembly Meiotic Cell Cycle Positive Regulation Of Helicase Activity Angiotensin-activated Signaling Pathway Chromosome Organization Cellular Response To Stimulus Viral Budding Response To Abiotic Stimulus Translesion Synthesis Aging
Tagcloud ?		adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky	2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants
Tagcloud (Difference) ?		adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky	2014genetics actionable advance atm cdkn2a chek2 counseling definitively deleterious doi genet germ gim guidelines heterozygote heterozygous identifies massively med msh2 online parallel pretest publication reportable susceptibility uncertain variant variants
Tagcloud (Intersection) ?