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SYMPK and SUMO1
Number of citations of the paper that reports this interaction (PMID
15561718
)
45
Data Source:
BioGRID
(enzymatic study)
SYMPK
SUMO1
Gene Name
symplekin
small ubiquitin-like modifier 1
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytoskeleton
Plasma Membrane
Tight Junction
Fibrillar Center
Nucleus
Nuclear Pore
Nucleoplasm
Nucleolus
Cytoplasm
PML Body
Nuclear Speck
Dendrite
Nuclear Membrane
Synapse
Molecular Function
Protein Binding
Protein Binding
Transcription Factor Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Poly(A) RNA Binding
Biological Process
MRNA Polyadenylation
Cell Adhesion
Positive Regulation Of Protein Dephosphorylation
DNA Repair
Protein Sumoylation
Cytokine-mediated Signaling Pathway
PML Body Organization
Positive Regulation Of Protein Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Localization
Negative Regulation Of DNA Binding
Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Palate Development
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Protein Localization To Nuclear Pore
Pathways
Interferon gamma signaling
SUMO is proteolytically processed
Post-translational protein modification
SUMOylation
Interferon Signaling
Cytokine Signaling in Immune system
SUMO is conjugated to E1 (UBA2:SAE1)
Regulation of IFNG signaling
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions
6 interactors:
CSTF2
HSF1
HTT
SSU72
SUMO1
TOP1
194 interactors:
ADD3
APP
AR
ARL13A
ATF2
ATF3
ATXN1
ATXN3
ATXN7
AURKA
AURKB
BCAM
BCL11A
BIRC3
BLM
BRCA1
C11orf65
C18orf25
CAMSAP2
CARD9
CASP2
CASP8
CCDC67
CD40
CDCA8
CHAF1A
CHD3
CHD4
COG1
CTNNA1
DAXX
DDX24
DNM1
DNMT3A
DNMT3B
DTX2
EDARADD
ESR1
ETV1
ETV4
ETV6
FADD
FAM118B
FANCM
FAS
FASLG
FBF1
FLI1
FOS
FOXL2
FOXM1
GATA1
GLP1R
GMCL1
HDAC4
HDAC9
HGS
HIF1A
HIPK2
HIPK3
HIRA
HNF4A
HNRNPC
HNRNPK
HSF1
HSF2
HTT
ING2
IRAK1
JUN
KAT2A
KAT6B
KDM1A
KRT14
KRT18
KRT5
KRT8
MAP2K1
MAPK1IP1L
MDC1
MDM2
MECOM
MEF2A
MEF2C
MITF
MKL1
MSX1
MUL1
MX1
MYB
NCOA1
NCOA2
NCOA3
NCOR2
NELFE
NFE2L2
NFKBIA
NIN
NOS1
NOX5
NR3C1
NR3C2
PARK7
PARP1
PAX6
PDGFC
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIK3C3
PLK3
PML
PPARA
PPM1J
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBM25
RHOXF2
RNF4
RPS3
SAE1
SALL1
SART1
SATB1
SEMA6A
SENP1
SENP2
SENP6
SETX
SH3KBP1
SLC2A1
SOX10
SOX2
SOX6
SP1
SP100
SP3
SREBF1
SREBF2
SSRP1
STAB2
STK24
STMN2
SUMO1P1
SUMO2
SUPT7L
SYMPK
TCERG1
TCF4
TDG
TDP2
TFCP2
TGM2
TNFRSF1A
TOE1
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP73
TRAF4
TRIM24
TRIM5
TRPS1
TSC22D3
TSHZ2
TSNAX
UBA2
UBE2I
USP25
USP7
USPL1
WNK1
WRN
XRCC1
XRCC5
ZBTB16
ZBTB26
ZBTB6
ZBTB7A
ZCCHC12
ZCCHC7
ZMYM2
ZMYM5
ZNF24
ZNF451
Entrez ID
8189
7341
HPRD ID
09090
03554
Ensembl ID
ENSG00000125755
ENSG00000116030
Uniprot IDs
Q92797
P63165
PDB IDs
3O2Q
3O2S
3O2T
3ODR
3ODS
4H3H
4H3K
1A5R
1TGZ
1WYW
1Y8R
1Z5S
2ASQ
2BF8
2G4D
2IO2
2IY0
2IY1
2KQS
2LAS
2PE6
2UYZ
2VRR
3KYC
3KYD
3RZW
3UIP
Enriched GO Terms of Interacting Partners
?
MRNA Polyadenylation
RNA Polyadenylation
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
MRNA 3'-end Processing
Neural Plate Formation
RNA 3'-end Processing
Serotonin Uptake
Lactate Biosynthetic Process From Pyruvate
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation
Regulation Of Protein Phosphatase Type 2A Activity
Protein Localization To Nucleus
Circadian Rhythm
PML Body Organization
Quinolinate Biosynthetic Process
Dephosphorylation Of RNA Polymerase II C-terminal Domain
Negative Regulation Of Synaptic Transmission, Dopaminergic
Lactate Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Localization To Nuclear Pore
Paraxial Mesoderm Formation
Quinolinate Metabolic Process
Protein Localization To Nuclear Envelope
Cellular Response To CGMP
Cellular Aromatic Compound Metabolic Process
Response To CGMP
Serotonin Transport
Regulation Of Gene Expression
Embryo Development
Sperm Ejaculation
Neural Plate Morphogenesis
L-glutamate Import
Regulation Of Developmental Growth
Rhythmic Process
Citrulline Metabolic Process
Embryonic Process Involved In Female Pregnancy
Lactate Metabolic Process
Urea Cycle
Embryonic Cleavage
Neurotransmitter Uptake
Urea Metabolic Process
Organelle Organization
Thalamus Development
Striatum Development
Paraxial Mesoderm Morphogenesis
Neural Plate Development
Amino Acid Import
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Metabolic Process
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Regulation Of Cell Death
Regulation Of Apoptotic Process
Biosynthetic Process
Cellular Metabolic Process
Regulation Of Cellular Process
Organelle Organization
Chromosome Organization
Cellular Response To Organic Substance
Protein Sumoylation
Cellular Response To Stimulus
Response To Organic Substance
Response To Stimulus
Developmental Process
Programmed Cell Death
Apoptotic Process
Peptidyl-lysine Modification
Tagcloud
?
aphidicolin
attachment
break
breakage
budding
cfs
covalent
excessive
fields
fragile
hallmark
modifier
ortholog
perturbed
pol32
pold3
polypeptides
proteomic
recombinational
replication
resource
rpa
ssdna
stresses
subfamily
sumo2
sumo3
sumoylation
Tagcloud (Difference)
?
aphidicolin
attachment
break
breakage
budding
cfs
covalent
excessive
fields
fragile
hallmark
modifier
ortholog
perturbed
pol32
pold3
polypeptides
proteomic
recombinational
replication
resource
rpa
ssdna
stresses
subfamily
sumo2
sumo3
sumoylation
Tagcloud (Intersection)
?