SYMPK and CSTF2

Number of citations of the paper that reports this interaction (PMID 10669729)
78

Data Source:
HPRD (in vitro)

		SYMPK	CSTF2
Gene Name		symplekin	cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Tight Junction	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Cleavage Body
	Molecular Function	Protein Binding	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Polyadenylation Cell Adhesion Positive Regulation Of Protein Dephosphorylation	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Cleavage RNA Splicing Gene Expression MRNA 3'-end Processing
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Processing of Capped Intronless Pre-mRNA mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CSTF2 HSF1 HTT SSU72 SUMO1 TOP1	23 interactors: APP BAG6 C14orf1 CHD3 CSTF3 DDX1 ECH1 EEF1G FEZ1 HGS IKBKAP IMMT KAT5 KIAA1377 POLR2A SPAG8 SS18L1 SUB1 SYMPK TFG UBQLN1 UBQLN4 ZNF341
Entrez ID		8189	1478
HPRD ID		09090	02652
Ensembl ID		ENSG00000125755	ENSG00000101811
Uniprot IDs		Q92797	E7EWR4 P33240
PDB IDs		3O2Q 3O2S 3O2T 3ODR 3ODS 4H3H 4H3K	1P1T 2J8P
Enriched GO Terms of Interacting Partners?		MRNA Polyadenylation RNA Polyadenylation Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA 3'-end Processing Neural Plate Formation RNA 3'-end Processing Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Regulation Of Protein Phosphatase Type 2A Activity Protein Localization To Nucleus Circadian Rhythm PML Body Organization Quinolinate Biosynthetic Process Dephosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Synaptic Transmission, Dopaminergic Lactate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Localization To Nuclear Pore Paraxial Mesoderm Formation Quinolinate Metabolic Process Protein Localization To Nuclear Envelope Cellular Response To CGMP Cellular Aromatic Compound Metabolic Process Response To CGMP Serotonin Transport Regulation Of Gene Expression Embryo Development Sperm Ejaculation Neural Plate Morphogenesis L-glutamate Import Regulation Of Developmental Growth Rhythmic Process Citrulline Metabolic Process Embryonic Process Involved In Female Pregnancy Lactate Metabolic Process Urea Cycle Embryonic Cleavage Neurotransmitter Uptake Urea Metabolic Process Organelle Organization Thalamus Development Striatum Development Paraxial Mesoderm Morphogenesis Neural Plate Development Amino Acid Import	MRNA Polyadenylation Gene Expression RNA Polyadenylation RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process MRNA Processing MRNA 3'-end Processing Regulation Of Protein Metabolic Process MRNA Metabolic Process RNA 3'-end Processing Regulation Of Gene Expression Regulation Of Metabolic Process RNA Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Transcription Elongation From RNA Polymerase II Promoter Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Nitrogen Compound Metabolic Process Regulation Of Dendrite Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Regulation Of Epidermal Growth Factor Receptor Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Regulation Of ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury DNA-templated Transcription, Elongation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Splicing Regulation Of Dendrite Development Collateral Sprouting Axon Midline Choice Point Recognition
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