SUMO1 and STK24

Number of citations of the paper that reports this interaction (PMID 17081986)
121

Data Source:
BioGRID (two hybrid)

		SUMO1	STK24
Gene Name		small ubiquitin-like modifier 1	serine/threonine kinase 24
Image
Gene Ontology Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm PML Body Nuclear Speck Dendrite Nuclear Membrane Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	DNA Repair Protein Sumoylation Cytokine-mediated Signaling Pathway PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Palate Development Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Localization To Nuclear Pore	Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Signal Transduction By Phosphorylation Negative Regulation Of Cell Migration Response To Hydrogen Peroxide Protein Autophosphorylation Regulation Of Axon Regeneration Execution Phase Of Apoptosis
Pathways		Interferon gamma signaling SUMO is proteolytically processed Post-translational protein modification SUMOylation Interferon Signaling Cytokine Signaling in Immune system SUMO is conjugated to E1 (UBA2:SAE1) Regulation of IFNG signaling SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Alzheimer's disease ( 22159054) Educational attainment ( 23722424) Longevity ( 20834067)
Protein-Protein Interactions		194 interactors: ADD3 APP AR ARL13A ATF2 ATF3 ATXN1 ATXN3 ATXN7 AURKA AURKB BCAM BCL11A BIRC3 BLM BRCA1 C11orf65 C18orf25 CAMSAP2 CARD9 CASP2 CASP8 CCDC67 CD40 CDCA8 CHAF1A CHD3 CHD4 COG1 CTNNA1 DAXX DDX24 DNM1 DNMT3A DNMT3B DTX2 EDARADD ESR1 ETV1 ETV4 ETV6 FADD FAM118B FANCM FAS FASLG FBF1 FLI1 FOS FOXL2 FOXM1 GATA1 GLP1R GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HIRA HNF4A HNRNPC HNRNPK HSF1 HSF2 HTT ING2 IRAK1 JUN KAT2A KAT6B KDM1A KRT14 KRT18 KRT5 KRT8 MAP2K1 MAPK1IP1L MDC1 MDM2 MECOM MEF2A MEF2C MITF MKL1 MSX1 MUL1 MX1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NELFE NFE2L2 NFKBIA NIN NOS1 NOX5 NR3C1 NR3C2 PARK7 PARP1 PAX6 PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3C3 PLK3 PML PPARA PPM1J RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBM25 RHOXF2 RNF4 RPS3 SAE1 SALL1 SART1 SATB1 SEMA6A SENP1 SENP2 SENP6 SETX SH3KBP1 SLC2A1 SOX10 SOX2 SOX6 SP1 SP100 SP3 SREBF1 SREBF2 SSRP1 STAB2 STK24 STMN2 SUMO1P1 SUMO2 SUPT7L SYMPK TCERG1 TCF4 TDG TDP2 TFCP2 TGM2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRIM5 TRPS1 TSC22D3 TSHZ2 TSNAX UBA2 UBE2I USP25 USP7 USPL1 WNK1 WRN XRCC1 XRCC5 ZBTB16 ZBTB26 ZBTB6 ZBTB7A ZCCHC12 ZCCHC7 ZMYM2 ZMYM5 ZNF24 ZNF451	11 interactors: CASP3 CASP7 CASP8 LRRK2 NEDD4 PDCD10 STK38L SUMO1 SUMO2 SUMO3 VAV2
Entrez ID		7341	8428
HPRD ID		03554	10385
Ensembl ID		ENSG00000116030	ENSG00000102572
Uniprot IDs		P63165	B4DR80 Q5U0E6 Q6P0Y1 Q9Y6E0
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP	3A7F 3A7G 3A7H 3A7I 3A7J 3CKW 3CKX 3ZHP
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Apoptotic Process Biosynthetic Process Cellular Metabolic Process Regulation Of Cellular Process Organelle Organization Chromosome Organization Cellular Response To Organic Substance Protein Sumoylation Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Developmental Process Programmed Cell Death Apoptotic Process Peptidyl-lysine Modification	Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Death Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Catalytic Activity Cardiovascular System Development Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Blood Vessel Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidase Activity Apoptotic Process Signal Transduction Response To Inorganic Substance Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Programmed Cell Death Positive Regulation Of Hydrolase Activity Protein Localization To Organelle Blood Vessel Development Protein Metabolic Process Vasculature Development Cellular Response To Organic Substance Regulation Of Metabolic Process
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	asset atxn1 atxn2 atxn3 atxn7 bioinformatic c5orf42 cacna1a cag celf2 crebbp ebf1 enriches melanogenesis moving nfia paxip1 plekhg4 polyq ppp2r2b sca screens spinocerebellar srsf4 tbp tremendous uguuu utrs ywhag
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo2 sumo3 sumoylation	asset atxn1 atxn2 atxn3 atxn7 bioinformatic c5orf42 cacna1a cag celf2 crebbp ebf1 enriches melanogenesis moving nfia paxip1 plekhg4 polyq ppp2r2b sca screens spinocerebellar srsf4 tbp tremendous uguuu utrs ywhag
Tagcloud (Intersection) ?